Results 291 to 300 of about 399,275 (342)

Cloning of a hypoxia inducible factor-1alpha and car-vascular homing peptide recombinant fusion protein template to psectag2-vector

, 2014
Antinmaa, Panu
openalex   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
ABSTRACT The cytosine (C) modifications 5‐methylcytosine (mC) and 5‐hydroxymethylcytosine (hmC) are central regulatory elements of mammalian genomes. Both marks occur in double‐stranded DNA in either strand‐symmetric or ‐asymmetric fashion, but it is still poorly understood how this symmetry information is selectively read out by the nuclear proteome ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated Rejection. [PDF]

Cells
Zhang J, Wei L, Song L, Lu X, Tan L, Li X, Fu L, Luo Q, Xie X, Zou Y.   +9 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Proinsulin-Loaded Nanoparticles Suppress Insulitis and Induce Temporary Diabetes Remission. [PDF]

Cells
Agapoff M, Dubreil C, Waeckel-Énée E, Geinguenaud F, Manceau V, Diana J, Bertocci B, Motte L, van Endert P.   +8 more
europepmc   +1 more source

Protein Engineering and Drug Discovery: Importance, Methodologies, Challenges, and Prospects. [PDF]

Biomolecules
Mohammed A, Ibrahim NA, Basher NS.
europepmc   +1 more source

Phage-Mediated Presentation of a Conserved HA2 Epitope From Influenza A Virus Elicits Significant IgY Antibody Responses in Broiler Chickens. [PDF]

Vet Med Sci
Lotfi Z, Golchin M, Shamshirgaran MA.
europepmc   +1 more source

Enhanced immunogenicity of COVID-19 RBD fused to mutant scorpion's phospholipase D for vaccine development. [PDF]

New Microbes New Infect
Zareinejad MR, Behdani M, Goodarzi MT, Oghalaie A, Hosseininejad-Chafi M, Pooshang-Bagheri K, Shahbazzadeh D.   +6 more
europepmc   +1 more source

Molecular Identification and Pathogenicity of a Chilli Veinal Mottle Virus Isolate from Sichuan, China. [PDF]

Int J Mol Sci
Chen C, Lu D, Lin X, Zhou X, Yang X.
europepmc   +1 more source