Results 61 to 70 of about 1,327,803 (301)

Is there NO treatment for severe sepsis? [PDF]

, 2008
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Novel and effective screening system for recombinant protein production in CHO cells

Scientific Reports
At present, biopharmaceuticals have received extensive attention from the society, among which recombinant proteins have a good growth trend and a large market share.
Junhe Zhang, Wenwen Yang, Liao Zhang, Wenqing Li, Xi Zhang, Xiaoyin Wang, Tianyun Wang   +6 more
doaj   +1 more source

Development of the Quality Evaluation System of High Protein Recombinant Rice by Principal Component Analysis

Shipin gongye ke-ji, 2022
In order to explore the relationship among quality indexes of high protein recombinant rice, 16 kinds of high protein recombinant rice were prepared by extrusion using broken rice and 16 kinds of common protein powder as raw materials.
Huiqing DENG, Weiguo WU, Luyan LIAO
doaj   +1 more source

Experimental Spinal Fusion With Recombinant Human Bone Morphogenetic Protein-2 Without Decortication of Osseous Elements [PDF]

, 1997
Study Design. L4-L5 intertransverse process fusions were produced with 58 μg, 230 μg, or 920 μg of recombinant human bone morphogenetic protein-2 in 20 dogs. Eleven had traditional decortication of posterior elements before insertion of the implant. Nine
Dawson, Edgar G., Delamarter, Rick B., Kabo, J. Michael, Kanim, Linda E.A., Liu, David, Sandhu, Harvinder, Toth, Jeffrey M.   +6 more
core   +1 more source

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]

, 2019
Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin, Brans, Toon, Declercq, Wim, Fraire, Juan, Raemdonck, Koen, Raes, Laurens, Roelandt, Ria, Saelens, Xavier, Stremersch, Stephan, Van Hoecke, Lien, Vandenabeele, Peter   +10 more
core   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein. [PDF]

, 1992
Several mycobacterial antigens, identified by monoclonal antibodies and patient sera, have been found to be homologous to stress or heat-shock proteins (hsp) defined in Escherichia coli and yeast.
Alland, D, Bajardi, AC, Bloom, BR, Brennan, PJ, Convit, J, Fan, XD, Grisso, CL, Hunter, SW, Mehra, V, Sieling, PA   +9 more
core  

Consensus mutagenesis reveals that non-helical regions influence thermal stability of horseradish peroxidase [PDF]

, 2008
The enzyme horseradish peroxidase has many uses in biotechnology but a stabilized derivative would have even wider applicability. To enhance thermal stability, we applied consensus mutagenesis (used successfully with other proteins) to recombinant ...
Amin, Arnold, Azevedo, Barry J. Ryan, Bonnaffe, Carlsson, Ciarán Ó'Fágáin, Dunford, Duroux, Eijsink, Eremin, Fishman, Flores, French, Gajhede, Garcia, Gonera, Grigorenko, Ignatenko, Kamal, Kamal, Kuhlmeyer, Lehmann, Lehmann, Lei, Lesk, Lin, Lipovsek, Liu, Magliery, Maniatis, Mary J. O'Connell, McEldoon, Miland, Miland, Miyazaki, Morawski, Nielsen, O'Brien, O'Brien, Pina, Ryan, Ryan, Ryan, Ryan, Ryan, Smith, Steipe, Tams, Thompson, van den Burg, Veitch, Wang, Watanabe, Welinder, Yang, Yang   +56 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source