Results 61 to 70 of about 2,327,860 (219)

Intravenous thrombolysis with recombinant tissue plasminogen activator in vascular warning syndromes

Neurología (English Edition), 2014
Introduction: Vascular warning syndromes constitute a neurological emergency due to their associated high risk of established stroke. At present, there is no strong evidence indicating the best treatment for these patients.
A. González Hernández, Ó. Fabre Pi, F. Cabrera Naranjo, A.C. López Veloso   +3 more
doaj   +1 more source

Cloning of the truncated Human tPA Gene in Chloroplast vector and regeneration of transplastomic tobacco plants [PDF]

مجله بیوتکنولوژی کشاورزی, 2014
Plants are suitable replacements for current biodrugs and recombinant protein expression systems such as transgenic animals or microbial systems. As the plant plastid genome is highly polyploid, the transformation of chloroplast permits the introduction ...
Maryam Abdoli Nasab, Mokhtar Jalali Javaran, Amin Baqi Zadeh, Houshang Alizadeh   +3 more
doaj   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Macular hole and submacular hemorrhage secondary to retinal arterial macroaneurysm – successfully treated with a novel surgical technique

GMS Ophthalmology Cases, 2020
Purpose: To present a 65-year-old patient with macular hole (MH) and submacular hemorrhage (SMH) secondary to a ruptured retinal arterial macroaneurysm (RAM) which was successfully treated with a novel surgical technique.Patient: A 65-year-old woman ...
Nourinia, Ramin, Behnaz, Nazanin, Hassanpour, Hossein, Karjoo, Zahra, Hassanpour, Kiana   +4 more
doaj   +1 more source

Recombinant tissue plasminogen activator following paediatric cataract surgery [PDF]

British Journal of Ophthalmology, 2000
The use of recombinant tissue plasminogen activator (r-TPA) has been advocated in the treatment of postsurgical fibrinous membrane formation following cataract surgery in adults. Its use in paediatric cases is not well documented.A retrospective review of paediatric cataract extractions performed at Moorfields Eye Hospital between 1 January 1997 and 4 ...
J S, Mehta, G G, Adams
openaire   +2 more sources

Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang, Chen Zhang, Jia‐Ni Chen, Fu‐Ying Cheng, Yi‐Zhang Wang, Shi‐Rui Xue, Huan Wang, De‐Hui Wang, Xi‐Cai Sun, Li Hu   +9 more
wiley   +1 more source

Impact of blood pressure variability on hemorrhagic transformation post-rt-PA thrombolysis in patients with acute ischemic stroke

SAGE Open Medicine
Background: The relationship between blood pressure variability and hemorrhagic transformation after recombinant tissue plasminogen activator thrombolysis in patients with acute ischemic stroke is uncertain due to inconsistent methodologies across ...
Sihan Liu, Jiadi Gao, Hanshu Zhao, Yuanqi Xu, Yubing Zhou, Yushuang Liu, Jinru Shen, Zhongling Zhang   +7 more
doaj   +1 more source

Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13 [PDF]

Scientific Reports, 2016
AbstractTissue plasminogen activator (tPA) is an effective treatment for ischemic stroke, but its neurotoxicity is a significant problem. Here we tested the hypothesis that recombinant ADAMTS 13 (rADAMTS 13) would reduce tPA neurotoxicity in a mouse model of stroke.
Mengchen Fan, Haochen Xu, Lixiang Wang, Haiyu Luo, Ximin Zhu, Ping Cai, Lixiang Wei, Lu Lu, Yongliang Cao, Rong Ye, Wenying Fan, Bing-Qiao Zhao   +11 more
openaire   +2 more sources

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

Efficacy and safety of tirofiban plus recombinant tissue plasminogen activator versus recombinant tissue plasminogen activator alone in acute ischemic stroke patients: a meta-analysis

Journal of Stroke and Cerebrovascular Diseases
Objective: Tirofiban plus recombinant tissue plasminogen activator (rtPA) shows good efficacy and safety in treating acute ischemic stroke (AIS) patients, but there is a lack of comprehensive assessment.
Yonghong Yang, MB, Qingwu Yang, MD
doaj   +1 more source