Results 81 to 90 of about 2,327,860 (219)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, Volume 13, Issue 61, 3 November 2026.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Intrapericardial instillation of recombinant tissue plasminogen activator: A case report

, 1998
On the 43rd day after open heart surgery, pericardial effusion developed in a patient and resulted in cardiac tamponade. Since the drainage could not be obtained by subxiphoid window technique due to location of fluid and presence of fibrinous adherence ...
Burma, O, Rahman, A, Uyar, IS, Ozdemir, F, Ilkay, E, Akkus, MN, Cekirdekci, AHMET   +6 more
core   +1 more source

Using low-dose tissue plasminogen activator through external ventricular drain and Cerebrolysin for the treatment of severe intraventricular hemorrhage: A case report

SAGE Open Medical Case Reports, 2020
Acute obstructive hydrocephalus is a complication of intraventricular hemorrhage, which requires a combination of medical and surgical treatments. We report a clinical case of intraventricular hemorrhage extension secondary to a ruptured arteriovenous ...
Nguyen Hoang Ngoc, Nguyen Van Tuyen
doaj   +1 more source

Recombinant lys-plasminogen, but not glu-plasminogen, improves recombinant tissue-type plasminogen activator-induced coronary thrombolysis in dogs

Journal of the American College of Cardiology, 1995
This study examined the modification of recombinant tissue-type plasminogen activator (rt-PA)-induced thrombolysis by recombinant lys-plasminogen.Recombinant tissue-type plasminogen activator restores flow in the thrombosed coronary artery, but the artery often reoccludes. The rt-PA-induced thrombolysis is a result of activation of plasminogen bound to
Department of Medicine, University of Florida College of Medicine, Veterans Affairs Medical Center, Gainesville, Florida, USA ( host institution ), Mehta, Jawahar L., Chen, Liying, Nichols, Wilmer W., Johannesen, Marie, Bregengrd, Claus, Hedner, Ulla, Saldeen, Tom G.P.   +7 more
openaire   +3 more sources

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, Volume 100, Issue 5, Page 964-978, November 2026.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Kellermann, Josef, Wilhelm, Olaf G., Riemer, Christoph, Bürgle, Markus, Schroeck, Florian, Schmitt, Manfred, Kessler, Horst, Degitz, Klaus, Arroyo de Prada, Nuria, Schmiedeberg, Niko, Magdolen, Viktor   +10 more
core   +1 more source

Recombinant human tissue plasminogen activator without heparin is effective in the treatment of hepatic veno-occlusive disease

, 1999
Recombinant human tissue plasminogen activator without heparin is effective in the treatment of hepatic veno-occlusive ...
Valdre L., Tani M., Vianelli N., Catani L., Tura S., Gherlinzoni F.   +5 more
core   +1 more source

Stability of Recombinant Tissue Plasminogen Activator at −30 °C over One Year

Pharmaceuticals, 2013
Recombinant tissue plasminogen activator (rt-PA) is used to restore patency and avoid inadvertent removal of peripheral and central venous catheters. rt-PA was reconstituted (1 mg/mL) then cryopreserved at −30 °C for 1, 2, 3, 6, 8, and
Abdulmalik Alkatheri
doaj   +1 more source

Activation of prothrombin accompanying thrombolysis with recombinant tissue-type plasminogen activator

Journal of the American College of Cardiology, 1992
Increases in thrombin activity in patients given fibrinolytic agents for acute myocardial infarction have been shown to be important in limiting the ultimate success of coronary thrombolysis. The present study was designed to determine whether increases in thrombin activity reflect, in part, activation of prothrombin accompanying thrombolysis.
Eisenberg, Paul R., Sobel, Burton E., Jaffe, Allan S.   +2 more
openaire   +2 more sources