Results 101 to 110 of about 2,327,860 (219)

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]

, 2012
Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Prem Kumar, Sutherland K Maciver, Manuel Salto-tellez, Celestial T. Yap (142210), Tochhawng, L., Zhuo, J., Celestial T Yap, Maciver, S.K., Koh, Shiuan, K. Maciver, Salto-Tellez Manuel, Manikandan Jayapal (64624), Tan, Ee Hong, Hooi, S., Jayapal, Manikandan, Maciver, Sutherland K., Yaw Chyn Lim (142208), Zhuo Jingli, Lalchhandami Tochhawng (142188), Jingli Zhuo, Ee Hong Tan (142182), Ee Hong Tan, Alan Prem Kumar (142201), Tay Hwee Kee, Lim, Yaw Chyn, Tay, H., Kumar, A.P., Tochhawng, Lalchhandami, Alan Prem Kumar, Maciver, Sutherland K, Ami Tochhawng, Koh, S., Salto-Tellez, M., Hwee Kee Tay (64625), Tay, H.K., Maciver, S., Benedict Yan (142185), Yap Celestial T., Kumar, Alan Prem, Shiuan Koh (142191), Lalchhandami Tochhawng, Lim, Y., Shing Chuan Hooi (50996), Jayapal Manikandan, Goh, Yaw Chong, Shiuan Koh, Tan, E.H., Yap, C., Yap, Celestial T, Yap, Celestial T., Tochhawng Lalchhandami, Tan, E., Lim, Y.C., Hooi, Shing Chuan, An Jayapal, Yan, B., Hwee Kee Tay, Hooi, S.C., Kumar Alan Prem, Sutherland K. Maciver (142194), Tan Ee Hong, Celestial T. Yap, Goh, Y., Manikandan Jayapal, Maciver Sutherland K., Goh Yaw Chong, Jingli Zhuo (142178), Zhuo, Jingli, Yap, C.T., Benedict Yan, Lim Yaw Chyn, Yan, Benedict, Jayapal, M., Yaw Chyn Lim, Goh, Y.C., Salto-Tellez, Manuel, Yaw Chong Goh, Yaw Chong Goh (142205), Koh Shiuan, Yan Benedict, Hooi Shing Chuan, Manuel Salto-Tellez (142198), Tay, Hwee Kee, Shing Chuan Hooi   +83 more
core   +2 more sources

Recombinant Tissue Plasminogen Activator for the Treatment of Acute Ischemic Stroke [PDF]

Baylor University Medical Center Proceedings, 2011
The use of recombinant tissue plasminogen activator (rtPA) has been the standard of care for treatment of acute ischemic stroke for several years. Studies evaluating the efficacy, safety, and optimal timing of rtPA use are ongoing. Recently, results of new studies led to expansion of the short timeframe from stroke symptom onset in which a patient can ...
openaire   +2 more sources

Improving the solubility, activity, and stability of reteplase using in silico design of new variants

Research in Pharmaceutical Sciences, 2019
Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and E. coli expressibility.
Hooria Seyedhosseini Ghaheh, Mohamad Reza Ganjalikhany, Parichehreh Yaghmaei, Morteza Pourfarzam, Hamid Mir Mohammad Sadeghi   +4 more
doaj   +1 more source

ROLE OF RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR IN THROMBOLYSIS

, 2020
Stroke or cerebrovascular accident is the sudden interruption of blood supply to brain, which is a medical emergency condition, and prompt treatment is crucial or may lead to fatal conditions or lifelong disability. Intravenous Tissue Plasminogen Activator (t-PA) was recognised and approved as the thrombolytic agent for acute ischemic stroke that can ...
openaire   +2 more sources

Rapid resolution of acute cor pulmonale with recombinant tissue plasminogen activator

, 2008
A case of massive pulmonary embolism complicated by acute cor pulmonale and shock is presented. The IV administration of recombinant tissue-type plasminogen activator (rt-PA) was associated with prompt reversal of clinical, ECG, and nuclear radiographic ...
Becker, Richard C., Gore, Joel M., Thompson, Michael J.   +2 more
core   +1 more source

Systemic Hematologic Status Following Intraventricular Recombinant Tissue-Type Plasminogen Activator for Intraventricular Hemorrhage

, 2011
Background and Purpose— This is the first prospective evaluation of changes in systemic hematologic status following administration of intraventricular recombinant tissue-type plasminogen activator in patients with ...
Nichol A. McBee, Daniel B. Herrick, Daniel F. Hanley, Carol B. Thompson, Karen Lane, Wendy C. Ziai   +5 more
core   +1 more source

Potential Eligibility for Recombinant Tissue Plasminogen Activator Therapy in Children: A Population-Based Study

, 2011
Intravenous recombinant tissue plasminogen activator is an established therapy for adults with ischemic stroke. In this Greater Cincinnati/Northern Kentucky population-based study, 8% were eligible.
Kathleen Alwell, Brett M. Kissela, Jane C. Khoury, Dawn O. Kleindorfer, Charles J. Moomaw, Laura L. Lehman, Pooja Khatri   +6 more
core   +1 more source

The Response of Hemostatic Marker Levels to Activated Factor VII in a Neonate following Cardiopulmonary Bypass

Case Reports in Medicine, 2009
The primary function of recombinant activated factor VII (rFVIIa) is to increase thrombin formation which leads to increased fibrin and less “bleeding.” As a result, most of literature utilizes “bleeding” as the outcome measure with respect to rFVIIa ...
Michael J. Eisses, Michael Richards, Denise Joffe, Jeremy M. Geiduschek, Wayne L. Chandler   +4 more
doaj   +1 more source

Full-dose thrombolysis for a right middle cerebral artery stroke after an acute aortic dissection

Annals of Indian Academy of Neurology, 2018
Intravenous recombinant tissue plasminogen activator (IV r-tpa) is the standard of care for patients suffering from neurological deficits due to an acute ischemic stroke within 4.5 hours in the absence of intracranial hemorrhage.
Syed Omar Kazmi, Oliver Achi, Rahul Damani   +2 more
doaj   +1 more source

Efficacy and safety of recombinant tissue plasminogen activator for venous thrombosis after paediatric heart surgery

, 2017
ObjectiveReports in the literature of treatment with recombinant tissue plasminogen activator following cardiac surgery are limited. We reviewed our experience to provide a case series of the therapeutic use of tissue plasminogen activator for the ...
David P. Nelson, Joseph Palumbo, Jaclyn Sawyer, Lindsey B. Justice, Manish N. Patel, Jonathan W. Byrnes   +5 more
core   +1 more source