Results 21 to 30 of about 318,801 (244)

Multiple mating but not recombination causes quantitative increase in offspring genetic diversity for varying genetic architectures. [PDF]

PLoS ONE, 2012
Explaining the evolution of sex and recombination is particularly intriguing for some species of eusocial insects because they display exceptionally high mating frequencies and genomic recombination rates. Explanations for both phenomena are based on the
Olav Rueppell, Stephen Meier, Roland Deutsch   +2 more
doaj   +1 more source

A high-resolution single nucleotide polymorphism genetic map of the mouse genome.

PLoS Biology, 2006
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans.
Sagiv Shifman, Jordana Tzenova Bell, Richard R Copley, Martin S Taylor, Robert W Williams, Richard Mott, Jonathan Flint   +6 more
doaj   +1 more source

Genetic Recombination and Molecular Evolution [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2009
Reduced rates of genetic recombination are often associated with reduced genetic variability and levels of adaptation. Several different evolutionary processes, collectively known as Hill-Robertson (HR) effects, have been proposed as causes of these correlates of recombination.
Charlesworth, B., Betancourt, A.J., Kaiser, V.B., Gordo, I.   +3 more
openaire   +3 more sources

Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

eLife, 2018
Recombination, the exchange of information between different genetic polymer strands, is of fundamental importance in biology for genome maintenance and genetic diversification and is mediated by dedicated recombinase enzymes. Here, we describe an innate
Hannes Mutschler, Alexander I Taylor, Benjamin T Porebski, Alice Lightowlers, Gillian Houlihan, Mikhail Abramov, Piet Herdewijn, Philipp Holliger   +7 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Homologous Recombination in Clostridioides difficile Mediates Diversification of Cell Surface Features and Transport Systems

mSphere, 2020
Illness caused by the pathogen Clostridioides difficile is widespread and can range in severity from mild diarrhea to sepsis and death. Strains of C. difficile isolated from human infections exhibit great genetic diversity, leading to the hypothesis that
Hannah D. Steinberg, Evan S. Snitkin
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Genetic analysis of variation in human meiotic recombination.

PLoS Genetics, 2009
The number of recombination events per meiosis varies extensively among individuals. This recombination phenotype differs between female and male, and also among individuals of each gender.
Reshmi Chowdhury, Philippe R J Bois, Eleanor Feingold, Stephanie L Sherman, Vivian G Cheung   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Identification and manipulation of the molecular determinants influencing poliovirus recombination.

PLoS Pathogens, 2013
The control and prevention of communicable disease is directly impacted by the genetic mutability of the underlying etiological agents. In the case of RNA viruses, genetic recombination may impact public health by facilitating the generation of new viral
Charles Runckel, Oscar Westesson, Raul Andino, Joseph L DeRisi   +3 more
doaj   +1 more source