Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution [PDF]
, 2010 Chromosomal rearrangements and copy number variants (CNVs) play key roles in genome evolution and genetic disease; however, the molecular mechanisms underlying these types of structural genomic variation are not fully understood.
Skinner, Benjamin M. +6 more
core +1 more source
G3: Genes, Genomes, Genetics, 2019 Meiotic recombination generates genetic diversity but in most species the number of crossovers per meiosis is limited. Previous modeling studies showed that increasing recombination can enhance response to selection.
Elise Tourrette +3 more
doaj +1 more source
Pan-cancer landscape of homologous recombination deficiency
Nature Communications, 2020 Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a genome-wide mutational scar-based pan-cancer Classifier of HOmologous Recombination Deficiency (CHORD ...
Luan Nguyen +3 more
semanticscholar +1 more source
Genetics, 2016 Meiotic recombination breaks down linkage disequilibrium (LD) and forms new haplotypes, meaning that it is an important driver of diversity in eukaryotic genomes.
S. Johnston +3 more
semanticscholar +1 more source
Comparative gene mapping in Arabidopsis lyrata chromosomes 6 and 7 and A thaliana chromosome IV: evolutionary history, rearrangements and local recombination rates [PDF]
, 2006 We have increased the density of genetic markers on the Arabidopsis lyrata chromosomes AL6 and AL7 corresponding to the A. thaliana chromosome IV, in order to determine chromosome rearrangements between these two species, and to compare recombination ...
Hansson, Bengt +9 more
core +1 more source
Multiple mating but not recombination causes quantitative increase in offspring genetic diversity for varying genetic architectures. [PDF]
PLoS ONE, 2012 Explaining the evolution of sex and recombination is particularly intriguing for some species of eusocial insects because they display exceptionally high mating frequencies and genomic recombination rates. Explanations for both phenomena are based on the
Olav Rueppell +2 more
doaj +1 more source
CRISPR-directed mitotic recombination enables genetic mapping without crosses
Science, 2016 Narrowing down genetic loci of interest Often it can be difficult to identify a gene or genetic region that underlies a specific trait. Traditional mapping relies on naturally occurring recombination events but can be limited in resolution by the natural
Meru J. Sadhu +3 more
semanticscholar +1 more source
A high-resolution single nucleotide polymorphism genetic map of the mouse genome.
PLoS Biology, 2006 High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans.
Sagiv Shifman +6 more
doaj +1 more source
Genealogy-based methods for inference of historical recombination and gene flow and their application in Saccharomyces cerevisiae [PDF]
, 2012 Genetic exchange between isolated populations, or introgression between species, serves as a key source of novel genetic material on which natural selection can act.
Brem, Rachel B. +11 more
core +1 more source
Swine Influenza A Evolution via Recombination - Genetic Drift Reservoir
, 2007 The looming influenza pandemic has focused attention^1-4^ on the rapid evolution of H5N1 and other human and avian serotypes. The basic tenets of influenza genetics^5^ define gradual changes as drifts caused by point mutations created by a polymerase ...
H. Niman
semanticscholar +1 more source