PLoS ONE, 2020 Characterizing meiotic recombination rates across the genomes of nonhuman primates is important for understanding the genetics of primate populations, performing genetic analyses of phenotypic variation and reconstructing the evolution of human ...
Cheng Xue +7 more
doaj +1 more source
Comparative gene mapping in Arabidopsis lyrata chromosomes 6 and 7 and A thaliana chromosome IV: evolutionary history, rearrangements and local recombination rates [PDF]
, 2006 We have increased the density of genetic markers on the Arabidopsis lyrata chromosomes AL6 and AL7 corresponding to the A. thaliana chromosome IV, in order to determine chromosome rearrangements between these two species, and to compare recombination ...
Hansson, Bengt +9 more
core +1 more source
Random-sequence genetic oligomer pools display an innate potential for ligation and recombination
eLife, 2018 Recombination, the exchange of information between different genetic polymer strands, is of fundamental importance in biology for genome maintenance and genetic diversification and is mediated by dedicated recombinase enzymes. Here, we describe an innate
Hannes Mutschler +7 more
doaj +1 more source
ama1 genes of sympatric Plasmodium vivax and P. falciparum from Venezuela differ significantly in genetic diversity and recombination frequency. [PDF]
, 2008 BACKGROUND: We present the first population genetic analysis of homologous loci from two sympatric human malaria parasite populations sharing the same human hosts, using full-length sequences of ama1 genes from Plasmodium vivax and P.
Sutherland, Colin J +6 more
core +3 more sources
Identification and manipulation of the molecular determinants influencing poliovirus recombination.
PLoS Pathogens, 2013 The control and prevention of communicable disease is directly impacted by the genetic mutability of the underlying etiological agents. In the case of RNA viruses, genetic recombination may impact public health by facilitating the generation of new viral
Charles Runckel +3 more
doaj +1 more source
Hierarchical Crossover in Genetic Algorithms [PDF]
, 1996 This paper identifies the limitations of conventional crossover in genetic algorithms when operating on two chromosomes of differing lengths. To address these problems, the concept of a Semantic Hierarchy (i.e.
Wakefield, Jonathan P. +1 more
core +4 more sources
mSphere, 2020 Illness caused by the pathogen Clostridioides difficile is widespread and can range in severity from mild diarrhea to sepsis and death. Strains of C. difficile isolated from human infections exhibit great genetic diversity, leading to the hypothesis that
Hannah D. Steinberg, Evan S. Snitkin
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligandâbinding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Single-crossover recombination and ancestral recombination trees [PDF]
, 2011 von Wangenheim U. Single-crossover recombination and ancestral recombination trees. Bielefeld: Universität Bielefeld; 2011.Modeling the process of recombination in the deterministic limit of an infinite population leads to a large coupled nonlinear ...
von Wangenheim, Ute
core
Genealogy-based methods for inference of historical recombination and gene flow and their application in Saccharomyces cerevisiae [PDF]
, 2012 Genetic exchange between isolated populations, or introgression between species, serves as a key source of novel genetic material on which natural selection can act.
Brem, Rachel B. +11 more
core +2 more sources