Results 41 to 50 of about 548,158 (296)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Identification and manipulation of the molecular determinants influencing poliovirus recombination.

PLoS Pathogens, 2013
The control and prevention of communicable disease is directly impacted by the genetic mutability of the underlying etiological agents. In the case of RNA viruses, genetic recombination may impact public health by facilitating the generation of new viral
Charles Runckel, Oscar Westesson, Raul Andino, Joseph L DeRisi   +3 more
doaj   +1 more source

Homologous Recombination in Clostridioides difficile Mediates Diversification of Cell Surface Features and Transport Systems

mSphere, 2020
Illness caused by the pathogen Clostridioides difficile is widespread and can range in severity from mild diarrhea to sepsis and death. Strains of C. difficile isolated from human infections exhibit great genetic diversity, leading to the hypothesis that
Hannah D. Steinberg, Evan S. Snitkin
doaj   +1 more source

Evidence for RNA recombination between distinct isolates of Pepino mosaic virus. [PDF]

, 2010
Genetic recombination plays an important role in the evolution of virus genomes. In this study we analyzed publicly available genomic sequences of Pepino mosaic virus (PepMV) for recombination events using several bioinformatics tools.
Hasiów-Jaroszewska, B., Kuzniar, A., Leunissen, J.A.M., Peters, S.A., Pospieszny, H.   +4 more
core   +1 more source

An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci [PDF]

, 2010
A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event
A. Eyre-Walker, A. Fox, A. S. Kondrashov, A. S. Kondrashov, A. S. Kondrashov, B. Balkau, B. Charlesworth, B. Charlesworth, B. Charlesworth, C. F. Baer, C. Hoede, E. Deutsch, F. A. Kondrashov, F. Ababneh, F. Rodríguez, F. Squartini, I. M. Singer, J. F. C. Kingman, J. F. C. Kingman, J. H. Wilkinson, J. J. Duistermaat, J. Keilson, J. R. Munkres, K. E. Holsinger, K. E. Holsinger, K. Holsinger, K. V. Pylkov, L. A. Zhivotovsky, L. A. Zhivotovsky, L. Altenberg, L. Altenberg, Lee Altenberg, M. Iosifescu, M. Lynch, M. Lynch, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Hirsch, R. A. Horn, R. C. Lewontin, R. N. Brandon, R. Teague, S. Karlin, S. Karlin, S. Karlin, S. Karlin, S. Karlin, S. P. Otto, S. Whelan, U. Liberman, U. Liberman, V. Guillemin, V. Jayaswal, W. C. Salmon, W. C. Salmon, W. Feller, Z. Yang, Z. Yang   +60 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Genetic Recombination in Bacteriophage {varphi}X174 [PDF]

, 1974
Genetic recombination in bacteriophage {varphi}X174 usually takes place early in the infection process and involves two parental replicative form (double-stranded) DNA molecules.
Benbow, Robert M., Davis, Gloria C., Sinsheimer, Robert L., Zuccarelli, Anthony J.   +3 more
core  

Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]

, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
A MacLeod, A MacLeod, A MacLeod, A Tait, A Tait, A Tait, A Tait, Andy Tait, Anneli Cooper, Annette MacLeod, BG Spratt, C. Michael R. Turner, CA Oura, Craig W. Duffy, CW Duffy, Daniel K. Masiga, DK Howe, EM Fevre, EM Fevre, F Balloux, F Mathieu-Daude, F Njiokou, FG Razakandrainibe, G Hide, G Hide, G Hide, HK Auty, HV Xong, J Maynard Smith, J Sternberg, Jeremy Sternberg, JJ McNamara, JR Stevens, L Berrang-Ford, L Jenni, L MacLean, L MacLean, L Peacock, L Peacock, Liam J. Morrison, Lindsay Sweeney, LJ Morrison, LJ Morrison, LJ Morrison, LJ Morrison, LM MacLean, Lorna MacLean, M Koffi, M Koffi, M Tibayrenc, M Tibayrenc, M Tibayrenc, NE Anderson, O Balmer, P Paindavoine, R Peakall, RD Page, RE Paul, RJ Pearce, SC Welburn, TJ Anderson, V Jamonneau, W Gibson, W Gibson, W Gibson, W Gibson, W Gibson, W Weir, WC Gibson, WC Gibson, Z Annan   +70 more
core   +6 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Genetic analysis of variation in human meiotic recombination.

PLoS Genetics, 2009
The number of recombination events per meiosis varies extensively among individuals. This recombination phenotype differs between female and male, and also among individuals of each gender.
Reshmi Chowdhury, Philippe R J Bois, Eleanor Feingold, Stephanie L Sherman, Vivian G Cheung   +4 more
doaj   +1 more source