Results 61 to 70 of about 356,079 (353)

Homologous Recombination in Clostridioides difficile Mediates Diversification of Cell Surface Features and Transport Systems

mSphere, 2020
Illness caused by the pathogen Clostridioides difficile is widespread and can range in severity from mild diarrhea to sepsis and death. Strains of C. difficile isolated from human infections exhibit great genetic diversity, leading to the hypothesis that
Hannah D. Steinberg, Evan S. Snitkin
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The influence of recombination on human genetic diversity. [PDF]

PLoS Genetics, 2006
In humans, the rate of recombination, as measured on the megabase scale, is positively associated with the level of genetic variation, as measured at the genic scale.
Chris C A Spencer, Panos Deloukas, Sarah Hunt, Jim Mullikin, Simon Myers, Bernard Silverman, Peter Donnelly, David Bentley, Gil McVean   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

sequenceLDhot: Detecting Recombination Hotspots. [PDF]

, 2006
Motivation: There is much local variation in recombination rates across the human genome—with the majority of recombination occuring in recombination hotspots—short regions of around ~2 kb in length that have much higher recombination rates than ...
Fearnhead, Paul
core  

Genetic analysis of variation in human meiotic recombination.

PLoS Genetics, 2009
The number of recombination events per meiosis varies extensively among individuals. This recombination phenotype differs between female and male, and also among individuals of each gender.
Reshmi Chowdhury, Philippe R J Bois, Eleanor Feingold, Stephanie L Sherman, Vivian G Cheung   +4 more
doaj   +1 more source

Bridge RNAs direct programmable recombination of target and donor DNA

Nature
Genomic rearrangements, encompassing mutational changes in the genome such as insertions, deletions or inversions, are essential for genetic diversity. These rearrangements are typically orchestrated by enzymes that are involved in fundamental DNA repair
Matthew G. Durrant, Nicholas T. Perry, James J. Pai, Aditya R. Jangid, Januka S. Athukoralage, M. Hiraizumi, John P McSpedon, April Pawluk, Hiroshi Nishimasu, Silvana Konermann, Patrick D. Hsu   +10 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing [PDF]

, 2012
BACKGROUND: Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod ...
Spooner Paul R, Ulrich Certa, Pelle, R., Richard P Bishop, Ebeling, M., Pelle Roger, Lucy Poveda, Roger Pelle, Küng, Erich, Morzaria, S., Henson, Sonal, Morzaria, S.P., Erich Küng, Bishop, Richard P., Daubenberger, C.A., Daubenberger, Claudia A., Certa, U., Spooner, Paul R, Poveda, Lucy, Paul R Spooner, Poveda, L., Ebeling, Martin, Certa, Ulrich, Claudia A Daubenberger, Spooner, P.R., Weihong Qi, Sonal Henson, Bishop Richard P, Spooner, Paul R., Certa Ulrich, Henson Sonal, Henson, S., Morzaria Subhash, Qi Weihong, Poveda Lucy, Subhash Morzaria, Bishop, R. P., Spooner, P. R., Kung, E., Pelle, Roger, Ebeling Martin, Küng Erich, Daubenberger Claudia A, Morzaria, Subhash, Daubenberger, C. A., Bishop, Richard P, Martin Ebeling, Qi, W., Qi, Weihong, Daubenberger, Claudia A   +49 more
core   +1 more source

Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females

G3: Genes, Genomes, Genetics, 2016
Meiotic recombination is a genetic process that is critical for proper chromosome segregation in many organisms. Despite being fundamental for organismal fitness, rates of crossing over vary greatly between taxa.
Chad M. Hunter, Matthew C. Robinson, David L. Aylor, Nadia D. Singh   +3 more
doaj   +1 more source