Results 81 to 90 of about 548,158 (296)

Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades [PDF]

, 2008
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997 1,2. The number of confirmed human cases now exceeds 300 and the associated Case Fatality Rate exceeds 60% 3.
Abdel-Satar Arafa, Ahmed E. Nayel, Ahmed S. Abdelghani, Bruce R. Boynton, Gregory A. Raczniak, Hala M. Esmat, Henry Niman, Mensah Agyen-Frempong, Mona M. Aly, Nasr El-Sayed, William K. Ampofo   +10 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Genome landscape and genetic architecture of recombination in domestic goats (Capra hircus)

Genetics Selection Evolution
Background Recombination is a fundamental biological process, both in participating to the creation of viable gametes and as a driver of genetic diversity. Characterising recombination is therefore of strong interest in breeding populations.
Alice Etourneau, Rachel Rupp, Bertrand Servin   +2 more
doaj   +1 more source

Clonality despite sex: the evolution of host-associated sexual neighborhoods in the pathogenic fungus Penicillium marneffei.

PLoS Pathogens, 2012
Molecular genetic approaches typically detect recombination in microbes regardless of assumed asexuality. However, genetic data have shown the AIDS-associated pathogen Penicillium marneffei to have extensive spatial genetic structure at local and ...
Daniel A Henk, Revital Shahar-Golan, Khuraijam Ranjana Devi, Kylie J Boyce, Nengyong Zhan, Natalie D Fedorova, William C Nierman, Po-Ren Hsueh, Kwok-Yung Yuen, Tran P M Sieu, Nguyen Van Kinh, Heiman Wertheim, Stephen G Baker, Jeremy N Day, Nongnuch Vanittanakom, Elaine M Bignell, Alex Andrianopoulos, Matthew C Fisher   +17 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Fungal clones win the battle, but recombination wins the war

IMA Fungus, 2019
Clonal reproduction is common in fungi and fungal-like organisms during epidemics and invasion events. The success of clonal fungi shaped systems for their classification and some pathogens are tacitly treated as asexual.
André Drenth, Alistair R. McTaggart, Brenda D. Wingfield   +2 more
doaj   +1 more source

Recombinant DNA Molecules of Bacteriophage phi X174 [PDF]

, 1975
phi X174 DNA structures containing two different parental genomes were detected genetically and examined by electron microscopy. These structures consisted of two monomeric double-stranded DNA molecules linked in a figure 8 configuration.
Benbow, Robert M., Sinsheimer, Robert L., Zuccarelli, Anthony J.   +2 more
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Genealogical Distance as a Diversity Estimate in Evolutionary Algorithms

, 2017
The evolutionary edit distance between two individuals in a population, i.e., the amount of applications of any genetic operator it would take the evolutionary process to generate one individual starting from the other, seems like a promising estimate ...
Belzner, Lenz, Gabor, Thomas
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source