Results 91 to 100 of about 356,079 (353)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Function of bacteriophage orf recombinasesin genetic exchange [PDF]

, 2006
Recombination events in bacteriophages frequently occur by illegitimate exchange at short tracts of sequence homology, enabling these viruses to acquire novel genes and serve as vehicles for horizontal gene transfer.
Reed, Patricia
core  

Automated phylogenetic detection of recombination using a genetic algorithm.

Molecular biology and evolution, 2006
The evolution of homologous sequences affected by recombination or gene conversion cannot be adequately explained by a single phylogenetic tree.
Sergei L. Kosakovsky Pond, D. Posada, M. Gravenor, C. Woelk, S. Frost   +4 more
semanticscholar   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Recombination confounds the early evolutionary history of human immunodeficiency virus type 1: Subtype G is a circulating recombinant form

, 2007
Human immunodeficiency virus type I (HIV-1) is classified in nine subtypes (A to D, F, G, H, J, and K), a number of subsubtypes, and several circulating recombinant forms (CRFs).
Vandamme, Anne-Mieke, Camacho, Ricardo, Lemey, Philippe, Vidal, Nicole, Rambaut, Andrew, Peeters, Martine, Abecasis, Ana B., de Oliveira, Tulio, Shapiro, Beth   +8 more
core   +1 more source

Tractable diffusion and coalescent processes for weakly correlated loci [PDF]

, 2015
Widely used models in genetics include the Wright-Fisher diffusion and its moment dual, Kingman's coalescent. Each has a multilocus extension but under neither extension is the sampling distribution available in closed-form, and their computation is ...
Fearnhead, Paul, Jenkins, Paul A, Song, Yun S., A. Jenkins, Paul, Song, Yun S, Jenkins, Paul, S. Song, Yun   +6 more
core   +1 more source

Detecting Genetic Recombination

, 2008
Recombination is the major motor of evolution. While mutations result in gradual changes, recombination reshuffles entire functional modules and thus progresses evolution in leaps and bounds. We need to identify recombination breakpoints in sequences to understand the evolutionary process, the impact of recombination, and to reconstruct the ...
openaire   +3 more sources

Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation

Genesis, 2013
Cre/LoxP‐mediated recombination allows for conditional gene activation or inactivation. When combined with an independent lineage‐tracing reporter allele, this technique traces the lineage of presumptive genetically modified Cre‐expressing cells. Several
Jing Liu, Spencer G. Willet, E. Bankaitis, Yanwen Xu, Chris Wright, Guoqiang Gu   +5 more
semanticscholar   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Diversity and recombination in Wolbachia and Cardinium from Bryobia spider mites [PDF]

, 2012
Background Wolbachia and Cardinium are endosymbiotic bacteria infecting many arthropods and manipulating host reproduction. Although these bacteria are maternally transmitted, incongruencies between phylogenies of host and parasite suggest an additional ...
Vera I D Ros, Edward J Feil, Johannes A J Breeuwer, Breeuwer, J.A.J., Fleming, V.M., Feil, E.J., Ros, V.I.D., Vicki M Fleming   +7 more
core   +1 more source