Results 41 to 50 of about 501,800 (253)
Competition between recombination and epistasis can cause a transition from allele to genotype selection [PDF]
, 2009 Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference
Neher, Richard A., Shraiman, Boris I.
core +3 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Statistical analysis on detecting recombination sites in DNA-beta satellites associated with the old world geminiviruses [PDF]
, 2010 Although an exchange of genetic information by recombination plays an important role in the evolution of viruses, it is not clear how it generates diversity.
Xu, Kai, Yoshida, Ruriko
core +4 more sources
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Protocol: Precision engineering of plant gene loci by homologous recombination cloning in Escherichia coli. [PDF]
, 2005 © 2005 Roden et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Göttgens, Berthold +2 more
core +5 more sources
Indirect stimulation of genetic recombination [PDF]
Proceedings of the National Academy of Sciences, 1983 Recombination between lac Z alleles in crosses of λ lac Z 1 - × λ lac Z 2 - and F - lac Z 1 - × λ lac
K. Brooks Low, Efim I. Golub
openaire +3 more sources
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
An Eco-Evolutionary approach of Adaptation and Recombination in a large population of varying size [PDF]
, 2014 We identify the genetic signature of a selective sweep in a population described by a birth-and-death process with density dependent competition. We study the limit behaviour for large K, where K scales the population size.
Smadi, Charline
core +4 more sources
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
A high-resolution single nucleotide polymorphism genetic map of the mouse genome [PDF]
, 2006 High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans.
Bell, Jordana Tzenova +7 more
core +5 more sources