Results 41 to 50 of about 541,645 (230)

Evidence for RNA recombination between distinct isolates of Pepino mosaic virus. [PDF]

, 2010
Genetic recombination plays an important role in the evolution of virus genomes. In this study we analyzed publicly available genomic sequences of Pepino mosaic virus (PepMV) for recombination events using several bioinformatics tools.
Hasiów-Jaroszewska, B., Kuzniar, A., Leunissen, J.A.M., Peters, S.A., Pospieszny, H.   +4 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

The influence of recombination on human genetic diversity. [PDF]

PLoS Genetics, 2006
In humans, the rate of recombination, as measured on the megabase scale, is positively associated with the level of genetic variation, as measured at the genic scale.
Chris C A Spencer, Panos Deloukas, Sarah Hunt, Jim Mullikin, Simon Myers, Bernard Silverman, Peter Donnelly, David Bentley, Gil McVean   +8 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Genetic analysis of variation in human meiotic recombination.

PLoS Genetics, 2009
The number of recombination events per meiosis varies extensively among individuals. This recombination phenotype differs between female and male, and also among individuals of each gender.
Reshmi Chowdhury, Philippe R J Bois, Eleanor Feingold, Stephanie L Sherman, Vivian G Cheung   +4 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Transcription as a Threat to Genome Integrity [PDF]

, 2016
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés, Gaillard, Hélène   +1 more
core   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females

G3: Genes, Genomes, Genetics, 2016
Meiotic recombination is a genetic process that is critical for proper chromosome segregation in many organisms. Despite being fundamental for organismal fitness, rates of crossing over vary greatly between taxa.
Chad M. Hunter, Matthew C. Robinson, David L. Aylor, Nadia D. Singh   +3 more
doaj   +1 more source

Bacterial microevolution and the Pangenome [PDF]

, 2020
The comparison of multiple genome sequences sampled from a bacterial population reveals considerable diversity in both the core and the accessory parts of the pangenome.
A Bankevich, AE Darling, AE Darling, AJ Page, AO Kislyuk, B Charlesworth, C Buckee, C Collins, C Wiuf, CM Thomas, CS Pepperell, DJ Wilson, DR Zerbino, E Jacox, F Lassalle, GE Sims, GJ Szollosi, GJ Szollosi, GJ Szollosi, H Ochman, IJ Wilson, J Hedge, J Lawrence, JB Joy, JFC Kingman, KAA Jolley, KE Dingle, KT Konstantinidis, L Li, L Petersen, M Csurös, M Nordborg, M Pagel, M Steinegger, M Touchon, M Vos, M Vos, M Vos, MJ Ward, MTG Holden, NA Rosenberg, NJ Croucher, P Donnelly, PAP Moran, R Griffiths, RC Griffiths, RG Everitt, RK Aziz, S Castillo-Ramírez, S Kurtz, S Wright, SF Altschul, SK Sheppard, SK Sheppard, SS Abby, SV Angiuoli, T Ohta, T Seemann, TG Vaughan, WP Maddison, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, Z Yang, Z Zhou   +68 more
core   +1 more source