Results 111 to 120 of about 8,966 (220)
PLoS Genetics, 2011 DNA double-strand breaks (DSBs) are potent sources of genome instability. While there is considerable genetic and molecular information about the disposition of direct DSBs and breaks that arise during replication, relatively little is known about DSBs ...
Wenjian Ma +3 more
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Recombinational Repair of a Chromosomal DNA Double Strand Break: A Dissertation
, 2009 Repairing a chromosomal DNA double strand break is essential for survival and maintenance of genomic integrity of a eukaryotic organism. The eukaryotic cell has therefore evolved intricate mechanisms to counteract all sorts of genomic insults in the ...
Sinha, Manisha
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Genetics and Molecular Biology, 1998 Molecular and functional homology between yeast proteins pRad51 and pRad52 and Escherichia coli pRecA involved in recombinational DNA repair led us to investigate possible effects of recA gene expression on DNA repair in rad51 and rad52 mutants of ...
M.A. Morais Jr. +5 more
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Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation
, 2005 In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C +3 more
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PLoS Genetics, 2010 Damage tolerance mechanisms mediating damage-bypass and gap-filling are crucial for genome integrity. A major damage tolerance pathway involves recombination and is referred to as template switch.
Fabio Vanoli +4 more
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Helicases and DNA dependent ATPases of Sulfolobus solfataricus
, 2008 Electronic version does not contain associated previously published materialDNA is susceptible to various types of damage as a result of normal cellular metabolism or from environmental sources.
Richards, Jodi D.
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DNA damage checkpoint and repair centers
, 2004 In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into focal assemblies. These foci are highly dynamic giga-dalton structures capable of simultaneously repairing multiple DNA lesions.
Lisby, Michael, Rothstein, Rodney
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The mechanism and evolution of recombinational repair.
, 1988 Recently, hydrogen peroxide (H₂O₂), and its free-radical product the hydroxyl radical (OH·), have been identified as major sources of DNA damage in living organisms.
Chen, Davis Shao-Hsuan.
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Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex [PDF]
, 2001 The structural maintenance of chromosomes (SMC) protein encoded by the fission yeast rad18 gene is involved in several DNA repair processes and has an essential function in DNA replication and mitotic control.
Moghraby, Jeelan S. +11 more
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Roles of Vertebrate Smc5 in Sister Chromatid Cohesion and Homologous Recombinational Repair
, 2011 The structural maintenance of chromosomes (Smc) family members Smc5 and Smc6 are both essential in budding and fission yeasts. Yeast smc5/6 mutants are hypersensitive to DNA damage, and Smc5/6 is recruited to HO-induced double-strand breaks (DSBs ...
Kliszczak, M. +9 more
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