Results 1 to 10 of about 27,662 (214)
Molecular & Cellular Oncology, 2022 RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation.
Younghoon Kee, Jung-Hee Lee, Ho Jin You
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Time-Dependent Induction of the Nucleotide Excision Repair Gene XPA and RAD51 in Homologous Recombination in Human Lymphocytes Exposed to Low Doses of Ionizing Radiation [PDF]
Iranian Journal of Medical Physics, 2022 Introduction: The aim of the present study was to understand the effect of low-doses of ionizing radiation (LDIR) on repair genes expression in blood samples that were taken from healthy donors.
Mohammad Taghi Bahreyni Toossi +2 more
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Characterization of t-loop formation by TRF2
Nucleus, 2020 T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ.
Leonid A. Timashev, Titia De Lange
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Open Medicine, 2023 Patients with castration-resistant prostate cancer (CRPC) often develop drug resistance after treatment with enzalutamide. The goal of our study was to identify the key genes related to enzalutamide resistance in CRPC and to provide new gene targets for ...
Xu Wen +9 more
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Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer
Medicina, 2020 Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in
Jae-Ho Lee, An-Na Bae, Soo-Jung Jung
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Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer
Cancer Cell International, 2021 Background Ovarian cancer has greatly endangered and deteriorated female health conditions worldwide. Refinement of predictive biomarkers could enable patient stratification and help optimize disease management.
Yuchen Feng +4 more
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Gut Microbes, 2020 Helicobacter pylori (H. pylori) infection is the strongest known risk factor for the development of gastric cancer. DNA damage response (DDR) and autophagy play key roles in tumorigenic transformation. However, it remains unclear how H.
Chuan Xie +12 more
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RAD51 is essential for spermatogenesis and male fertility in mice
Cell Death Discovery, 2022 The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, the physiological role of RAD51 during spermatogenesis remains unclear since RAD51 null mutation is embryonic ...
Junchao Qin +9 more
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Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]
Network Biology, 2020 There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad +2 more
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Nature Communications, 2023 ATP-dependent RAD51 recombinases play an essential role in eukaryotic homologous recombination by catalyzing a four-step process: 1) formation of a RAD51 single-filament assembly on ssDNA in the presence of ATP, 2) complementary DNA strand-exchange, 3 ...
Shih-Chi Luo +7 more
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