Results 1 to 10 of about 28,253 (118)
Frontiers in Oncology, 2022 BackgroundRAD51, a critical protein for DNA repairment, has been found to associate with multiple cancer types, but, so far, a systematic pan-cancer analysis of RAD51 has not been done yet.MethodsData were obtained from multiple open databases and ...
Hengrui Liu
exaly +3 more sources
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia
EMBO Molecular Medicine, 2013 RAD51 recombinase activity plays a critical role for cancer cell proliferation and survival, and often contributes to drug‐resistance. Abnormally elevated RAD51 function and hyperactive homologous recombination (HR) rates have been found in a panel of ...
Phang-Lang Chen +2 more
exaly +2 more sources
Time-Dependent Induction of the Nucleotide Excision Repair Gene XPA and RAD51 in Homologous Recombination in Human Lymphocytes Exposed to Low Doses of Ionizing Radiation [PDF]
Iranian Journal of Medical Physics, 2022 Introduction: The aim of the present study was to understand the effect of low-doses of ionizing radiation (LDIR) on repair genes expression in blood samples that were taken from healthy donors.
Mohammad Taghi Bahreyni Toossi +2 more
doaj +1 more source
Molecular & Cellular Oncology, 2022 RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation.
Younghoon Kee, Jung-Hee Lee, Ho Jin You
doaj +1 more source
Open Medicine, 2023 Patients with castration-resistant prostate cancer (CRPC) often develop drug resistance after treatment with enzalutamide. The goal of our study was to identify the key genes related to enzalutamide resistance in CRPC and to provide new gene targets for ...
Xu Wen +9 more
doaj +1 more source
Characterization of t-loop formation by TRF2
Nucleus, 2020 T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ.
Leonid A. Timashev, Titia De Lange
doaj +1 more source
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer
Cancer Cell International, 2021 Background Ovarian cancer has greatly endangered and deteriorated female health conditions worldwide. Refinement of predictive biomarkers could enable patient stratification and help optimize disease management.
Yuchen Feng +4 more
doaj +1 more source
Mapping the breakome reveals tight regulation on oncogenic super-enhancers
Molecular & Cellular Oncology, 2020 DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling
Sara Oster, Rami I. Aqeilan
doaj +1 more source
Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]
Network Biology, 2020 There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad +2 more
doaj
Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer
Medicina, 2020 Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in
Jae-Ho Lee, An-Na Bae, Soo-Jung Jung
doaj +1 more source