Results 11 to 20 of about 27,662 (214)
Cells, 2023 Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount role(s) in genome plasticity. The pivotal HR step is the strand invasion/exchange of double-stranded DNA by a homologous single-stranded DNA (ssDNA) covered by RAD51 ...
Mélissa Thomas +4 more
doaj +3 more sources
PLoS ONE, 2015 Expression of RAD51, a crucial player in homologous recombination (HR) and DNA double-strand break (DSB) repair, is dysregulated in human tumors, and can contribute to genomic instability and tumor progression.
Inbal Gazy +10 more
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Mechanism of Replication Fork Reversal and Protection by Human RAD51 and RAD51 Paralogs [PDF]
SSRN Electronic Journal, 2020 Abstract SMARCAL1, ZRANB3 and HLTF are all required for the remodeling of replication forks upon stress. Using reconstituted reactions, we show that the motor proteins have unequal biochemical capacities, explaining why they have non-redundant functions.
Petr Cejka +9 more
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Regulation of Rad51 promoter [PDF]
Cell Cycle, 2014 The DNA double-strand break repair and homologous recombination protein Rad51 is overexpressed in the majority of human cancers. This correlates with therapy resistance and decreased patient survival. We previously showed that constructs containing Rad51 promoter fused to a reporter gene are, on average, 850-fold more active in cancer cells than in ...
Christopher M, Hine +5 more
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Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction [PDF]
Nucleic Acids Research, 2013 RAD51 DNA strand exchange protein catalyzes the central step in homologous recombination, a cellular process fundamentally important for accurate repair of damaged chromosomes, preservation of the genetic integrity, restart of collapsed replication forks and telomere maintenance.
Subramanyam, Shyamal +3 more
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Mapping the breakome reveals tight regulation on oncogenic super-enhancers
Molecular & Cellular Oncology, 2020 DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling
Sara Oster, Rami I. Aqeilan
doaj +1 more source
BRCA1-BARD1: the importance of being in shape
Molecular & Cellular Oncology, 2019 The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation.
Manuel Daza-Martin +2 more
doaj +1 more source
Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases
Nature Communications, 2023 Central to homologous recombination (HR) is the assembly of Rad51 recombinase on single-strand DNA (ssDNA), forming the Rad51-ssDNA filament. How the Rad51 filament is efficiently established and sustained remains partially understood. Here, we find that
Guangxue Liu +14 more
doaj +1 more source
Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
Nature Communications, 2023 The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the DNA-strand exchange RAD51 protein in homology-directed repair.
Robert Appleby +3 more
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Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation [PDF]
Nature, 2011 Homologous recombination is a high-fidelity DNA repair pathway. Besides a critical role in accurate chromosome segregation during meiosis, recombination functions in DNA repair and in the recovery of stalled or broken replication forks to ensure genomic stability.
Liu, Jie +5 more
openaire +6 more sources