Results 11 to 20 of about 27,541 (198)
Molecular & Cellular Oncology, 2022 RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation.
Younghoon Kee, Jung-Hee Lee, Ho Jin You
doaj +4 more sources
Cells, 2023 Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount role(s) in genome plasticity. The pivotal HR step is the strand invasion/exchange of double-stranded DNA by a homologous single-stranded DNA (ssDNA) covered by RAD51 ...
Mélissa Thomas +4 more
doaj +3 more sources
Frontiers in Oncology, 2022 BackgroundRAD51, a critical protein for DNA repairment, has been found to associate with multiple cancer types, but, so far, a systematic pan-cancer analysis of RAD51 has not been done yet.MethodsData were obtained from multiple open databases and ...
Hengrui Liu, Jieling Weng
exaly +3 more sources
A novel small molecule RAD51 inactivator overcomes imatinib‐resistance in chronic myeloid leukaemia
EMBO Molecular Medicine, 2013 RAD51 recombinase activity plays a critical role for cancer cell proliferation and survival, and often contributes to drug‐resistance. Abnormally elevated RAD51 function and hyperactive homologous recombination (HR) rates have been found in a panel of ...
Jiewen Zhu, Guikai Wu, Heiko KÖNIG
exaly +2 more sources
PLoS ONE, 2015 Expression of RAD51, a crucial player in homologous recombination (HR) and DNA double-strand break (DSB) repair, is dysregulated in human tumors, and can contribute to genomic instability and tumor progression.
Inbal Gazy +10 more
doaj +4 more sources
Time-Dependent Induction of the Nucleotide Excision Repair Gene XPA and RAD51 in Homologous Recombination in Human Lymphocytes Exposed to Low Doses of Ionizing Radiation [PDF]
Iranian Journal of Medical Physics, 2022 Introduction: The aim of the present study was to understand the effect of low-doses of ionizing radiation (LDIR) on repair genes expression in blood samples that were taken from healthy donors.
Mohammad Taghi Bahreyni Toossi +2 more
doaj +1 more source
Open Medicine, 2023 Patients with castration-resistant prostate cancer (CRPC) often develop drug resistance after treatment with enzalutamide. The goal of our study was to identify the key genes related to enzalutamide resistance in CRPC and to provide new gene targets for ...
Xu Wen +9 more
doaj +1 more source
Mechanism of Replication Fork Reversal and Protection by Human RAD51 and RAD51 Paralogs [PDF]
SSRN Electronic Journal, 2020 Abstract SMARCAL1, ZRANB3 and HLTF are all required for the remodeling of replication forks upon stress. Using reconstituted reactions, we show that the motor proteins have unequal biochemical capacities, explaining why they have non-redundant functions.
Petr Cejka +9 more
openaire +1 more source
Characterization of t-loop formation by TRF2
Nucleus, 2020 T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ.
Leonid A. Timashev, Titia De Lange
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Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer
Cancer Cell International, 2021 Background Ovarian cancer has greatly endangered and deteriorated female health conditions worldwide. Refinement of predictive biomarkers could enable patient stratification and help optimize disease management.
Yuchen Feng +4 more
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