Results 11 to 20 of about 35,752 (235)
Cells, 2023 Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount role(s) in genome plasticity. The pivotal HR step is the strand invasion/exchange of double-stranded DNA by a homologous single-stranded DNA (ssDNA) covered by RAD51 ...
Mélissa Thomas +4 more
doaj +4 more sources
PLoS ONE, 2015 Expression of RAD51, a crucial player in homologous recombination (HR) and DNA double-strand break (DSB) repair, is dysregulated in human tumors, and can contribute to genomic instability and tumor progression.
Inbal Gazy +10 more
doaj +5 more sources
eLife, 2018 Homology search and strand exchange mediated by Rad51 nucleoprotein filaments are key steps of the homologous recombination process. In budding yeast, Rad52 is the main mediator of Rad51 filament formation, thereby playing an essential role.
Emilie Ma +5 more
doaj +2 more sources
Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption [PDF]
Nucleic Acids Research, 2009 The SRS2 (Suppressor of RAD Six screen mutant 2) gene encodes an ATP-dependent DNA helicase that regulates homologous recombination in Saccharomyces cerevisiae. Mutations in SRS2 result in a hyper-recombination phenotype, sensitivity to DNA damaging agents and synthetic lethality with mutations that affect DNA metabolism.
Colavito, Sierra +7 more
openaire +3 more sources
Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination [PDF]
Cell, 2015 Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes strand exchange with homologous duplex DNA. BRCA2 and the Rad51 paralogs are tumor suppressors and critical mediators of Rad51.
Taylor, MRG +10 more
openaire +6 more sources
RAD51AP1 is a versatile RAD51 modulator
Proceedings of the National Academy of SciencesRAD51AP1 is an emergent key factor in homologous recombination (HR), the major pathway for accurate repair of DNA double-strand breaks, and in alternative lengthening of telomeres (ALT). Depletion of RAD51AP1 diminishes HR and overexpression is common in cancer, where it is associated with malignancy.
Lucas Kuhlen +5 more
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Evaluating the efficacy of DNA repair biomarkers to assess human cell response to chemotherapy using imaging flow cytometry [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Chemotherapy and radiotherapy are widely accepted as common forms of treatment for cancers. The majority of cancer patients receive chemotherapy alone or in
Zahir, Sheba Adam
core +7 more sources
Mechanism of Replication Fork Reversal and Protection by Human RAD51 and RAD51 Paralogs [PDF]
SSRN Electronic Journal, 2020 Abstract SMARCAL1, ZRANB3 and HLTF are all required for the remodeling of replication forks upon stress. Using reconstituted reactions, we show that the motor proteins have unequal biochemical capacities, explaining why they have non-redundant functions.
Petr Cejka +9 more
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Regulation of Rad51 promoter [PDF]
Cell Cycle, 2014 The DNA double-strand break repair and homologous recombination protein Rad51 is overexpressed in the majority of human cancers. This correlates with therapy resistance and decreased patient survival. We previously showed that constructs containing Rad51 promoter fused to a reporter gene are, on average, 850-fold more active in cancer cells than in ...
Christopher M, Hine +5 more
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Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction [PDF]
Nucleic Acids Research, 2013 RAD51 DNA strand exchange protein catalyzes the central step in homologous recombination, a cellular process fundamentally important for accurate repair of damaged chromosomes, preservation of the genetic integrity, restart of collapsed replication forks and telomere maintenance.
Subramanyam, Shyamal +3 more
openaire +2 more sources