Results 21 to 30 of about 35,752 (235)

Isolation, characterisation and expression patterns of a RAD51 ortholog from Pleurotus ostreatus [PDF]

, 2002
AB: Using degenerated primers for conserved regions of RecA homologs we have isolated a gene from Pleurotus ostreatus that shows characteristic features of RAD51 homologs. The encoded amino acid sequence of P.
Griensven, L.J.L.D., van, Sonnenberg, A.S.M., Mikosch, T.S.P.   +2 more
core   +1 more source

RAD51 is essential for spermatogenesis and male fertility in mice

Cell Death Discovery, 2022
The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, the physiological role of RAD51 during spermatogenesis remains unclear since RAD51 null mutation is embryonic ...
Junchao Qin, Tao Huang, Jing Wang, Limei Xu, Qianli Dang, Xiuhua Xu, Hongbin Liu, Zhaojian Liu, Changshun Shao, Xiyu Zhang   +9 more
doaj   +1 more source

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity [PDF]

, 2011
The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks.
Rajendra, Eason, Skylaris Chris-Kriton, Cole, Daniel J., Venkitaraman Ashok R., Hardwick, Bryn, Payne, Mike C., Mike C. Payne, McKenzie, Grahame J., Grahame J. McKenzie, Cole Daniel J., Mike C Payne, Hardwick Bryn, McKenzie Grahame J., Bryn Hardwick, Grahame J McKenzie, Ashok R Venkitaraman, Chris-Kriton Skylaris, Daniel J Cole, Ashok R. Venkitaraman, Eeson Rajendra, Roberts-Thomson Meredith, Skylaris, Chris-Kriton, Payne Mike C., Kowalczykowski, Stephen Charles, Venkitaraman, Ashok R., Rajendra Eeson, Roberts-Thomson, Meredith, Daniel J. Cole, Meredith Roberts-Thomson   +28 more
core   +3 more sources

A RAD51–ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination

Nature Communications, 2023
ATP-dependent RAD51 recombinases play an essential role in eukaryotic homologous recombination by catalyzing a four-step process: 1) formation of a RAD51 single-filament assembly on ssDNA in the presence of ATP, 2) complementary DNA strand-exchange, 3 ...
Shih-Chi Luo, Min-Chi Yeh, Yu-Hsiang Lien, Hsin-Yi Yeh, Huei-Lun Siao, I-Ping Tu, Peter Chi, Meng-Chiao Ho   +7 more
doaj   +1 more source

Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation [PDF]

, 2005
In Trypanosoma brucei, DNA recombination is crucial in antigenic variation, a strategy for evading the mammalian host immune system found in a wide variety of pathogens.
Proudfoot, C, McCulloch, Richard, Proudfoot, Christopher, McCulloch, R   +3 more
core   +1 more source

Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection

Gut Microbes, 2020
Helicobacter pylori (H. pylori) infection is the strongest known risk factor for the development of gastric cancer. DNA damage response (DDR) and autophagy play key roles in tumorigenic transformation. However, it remains unclear how H.
Chuan Xie, Nianshuang Li, Huan Wang, Cong He, Yi Hu, Chao Peng, Yaobin Ouyang, Dejie Wang, Yong Xie, Jiang Chen, Xu Shu, Yin Zhu, Nonghua Lu   +12 more
doaj   +1 more source

Structure of the hDmc1-ssDNA filament reveals the principles of its architecture [PDF]

, 2010
In eukaryotes, meiotic recombination is a major source of genetic diversity, but its defects in humans lead to abnormalities such as Down's, Klinefelter's and other syndromes.
Dmitry V Bugreev, Julie Hodgkinson, Yuriy L Chaban, Bugreev, DV, Orlova, Elena, Orlova, EV, Hodgkinson, J.L., Orlova Elena V., Chaban, Y.L., Bugreev, D.V., Andrei L Okorokov, Chaban Yuriy L., Okorokov, AL, Elena V Orlova, Okorokov, A.L., Hodgkinson, J, Bugreev Dmitry V., Chaban, YL, Okorokov Andrei L., Mazin, AV, Hodgkinson Julie, Mazin, A.V., Alexander V Mazin, Mazin Alexander V.   +23 more
core   +2 more sources

Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases

Nature Communications, 2023
Central to homologous recombination (HR) is the assembly of Rad51 recombinase on single-strand DNA (ssDNA), forming the Rad51-ssDNA filament. How the Rad51 filament is efficiently established and sustained remains partially understood. Here, we find that
Guangxue Liu, Jimin Li, Boxue He, Jiaqi Yan, Jingyu Zhao, Xuejie Wang, Xiaocong Zhao, Jingyan Xu, Yeyao Wu, Simin Zhang, Xiaoli Gan, Chun Zhou, Xiangpan Li, Xinghua Zhang, Xuefeng Chen   +14 more
doaj   +1 more source

Three-color dSTORM images of wild type and Hormad1^-/- nuclear surface spread spermatocytes immunostained for SYCP3-RAD51-DMC1.

, 2022
A) dSTORM and B) close-up of boxed region shown in A) image of wild type mid-zygotene nucleus immunostained for SYCP3 (magenta), RAD51 (red) and DMC1 (green).
Marco Barchi (47160), Joost Gribnau (73206), Adriaan B. Houtsmuller (8940029), Wiggert A. van Cappellen (8940026), Johan A. Slotman (3981806), Attila Tóth (2847734), Esther Sleddens-Linkels (209679), Willy M. Baarends (8940032), Lieke Koornneef (8940023)   +8 more
core   +1 more source

Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2

Nature Communications, 2023
The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the DNA-strand exchange RAD51 protein in homology-directed repair.
Robert Appleby, Luay Joudeh, Katie Cobbett, Luca Pellegrini   +3 more
doaj   +1 more source