Results 21 to 30 of about 27,662 (214)
Cancer Cell International, 2023 Objectives RAD51 overexpression has been reported to serve as a marker of poor prognosis in several cancer types. This study aimed to survey the role of RAD51 in oral squamous cell carcinoma and whether RAD51 could be a potential therapeutic target ...
Yu-Fen Tsai +6 more
doaj +1 more source
Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption [PDF]
Nucleic Acids Research, 2009 The SRS2 (Suppressor of RAD Six screen mutant 2) gene encodes an ATP-dependent DNA helicase that regulates homologous recombination in Saccharomyces cerevisiae. Mutations in SRS2 result in a hyper-recombination phenotype, sensitivity to DNA damaging agents and synthetic lethality with mutations that affect DNA metabolism.
Colavito, Sierra +7 more
openaire +2 more sources
Molecular Determinant of DIDS Analogs Targeting RAD51 Activity
Molecules, 2021 RAD51 is the central protein in DNA repair by homologous recombination (HR), involved in several steps of this process. It is shown that overexpression of the RAD51 protein is correlated with increased survival of cancer cells to cancer treatments.
Denis Velic +6 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2019 Candida albicans, the most common fungal pathogen, is a diploid with a genome that is rich in repeats and has high levels of heterozygosity. To study the role of different recombination pathways on direct-repeat recombination, we replaced either allele ...
Alberto Bellido +5 more
doaj +1 more source
Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
International Journal of General Medicine, 2022 Yaqin Shi,1,* Meng Shen,1,* Mengdan Xu,1 Min Tao,1 Kai Chen,1 Qingqing Zhu2 1Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Respiratory Medicine, The First ...
Shi Y +5 more
doaj
St. Petersburg Polytechnical University Journal: Physics and MathematicsNucleoprotein filaments formed by recombinase proteins on DNA are key structures of the homologous recombination process, which ensures the maintenance of the genome stability.
Goncharov Ivan +7 more
doaj +1 more source
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. [PDF]
PLoS ONE, 2017 BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined.
Yan Li +7 more
doaj +1 more source
RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
Nucleic Acids Research, 2023 Abstract Fork reversal is a conserved mechanism to prevent stalled replication forks from collapsing. Formation and protection of reversed forks are two crucial steps in ensuring fork integrity and stability. Five RAD51 paralogs, namely, RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, which share sequence and structural similarity to the ...
Chia-Lun Guh +8 more
openaire +2 more sources
Cancer Management and Research, 2020 Songwei Huan,1,* Tao Gui,1,* Qiutong Xu,1,* Songkuan Zhuang,2 Zhenyan Li,1 Yuling Shi,3 Jiebin Lin,3 Bin Gong,1 Guiqiang Miao,1 Manseng Tam,4 Huan-Tian Zhang,1 Zhengang Zha,1 Chunfei Wu3 1Institute of Orthopedic Diseases and Department of Bone and Joint ...
Huan S +12 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source