Results 21 to 30 of about 27,541 (198)
Regulation of Rad51 promoter [PDF]
Cell Cycle, 2014 The DNA double-strand break repair and homologous recombination protein Rad51 is overexpressed in the majority of human cancers. This correlates with therapy resistance and decreased patient survival. We previously showed that constructs containing Rad51 promoter fused to a reporter gene are, on average, 850-fold more active in cancer cells than in ...
Christopher M, Hine +5 more
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Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction [PDF]
Nucleic Acids Research, 2013 RAD51 DNA strand exchange protein catalyzes the central step in homologous recombination, a cellular process fundamentally important for accurate repair of damaged chromosomes, preservation of the genetic integrity, restart of collapsed replication forks and telomere maintenance.
Subramanyam, Shyamal +3 more
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Mapping the breakome reveals tight regulation on oncogenic super-enhancers
Molecular & Cellular Oncology, 2020 DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling
Sara Oster, Rami I. Aqeilan
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RAD51 is essential for spermatogenesis and male fertility in mice
Cell Death Discovery, 2022 The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, the physiological role of RAD51 during spermatogenesis remains unclear since RAD51 null mutation is embryonic ...
Junchao Qin +9 more
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Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer
Medicina, 2020 Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in
Jae-Ho Lee, An-Na Bae, Soo-Jung Jung
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Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]
Network Biology, 2020 There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad +2 more
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Nature Communications, 2023 ATP-dependent RAD51 recombinases play an essential role in eukaryotic homologous recombination by catalyzing a four-step process: 1) formation of a RAD51 single-filament assembly on ssDNA in the presence of ATP, 2) complementary DNA strand-exchange, 3 ...
Shih-Chi Luo +7 more
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Gut Microbes, 2020 Helicobacter pylori (H. pylori) infection is the strongest known risk factor for the development of gastric cancer. DNA damage response (DDR) and autophagy play key roles in tumorigenic transformation. However, it remains unclear how H.
Chuan Xie +12 more
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Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases
Nature Communications, 2023 Central to homologous recombination (HR) is the assembly of Rad51 recombinase on single-strand DNA (ssDNA), forming the Rad51-ssDNA filament. How the Rad51 filament is efficiently established and sustained remains partially understood. Here, we find that
Guangxue Liu +14 more
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Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption [PDF]
Nucleic Acids Research, 2009 The SRS2 (Suppressor of RAD Six screen mutant 2) gene encodes an ATP-dependent DNA helicase that regulates homologous recombination in Saccharomyces cerevisiae. Mutations in SRS2 result in a hyper-recombination phenotype, sensitivity to DNA damaging agents and synthetic lethality with mutations that affect DNA metabolism.
Colavito, Sierra +7 more
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