Results 41 to 50 of about 35,752 (235)

Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. [PDF]

PLoS ONE, 2017
BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined.
Yan Li, Wei-Ya Wang, Jiang-Hong Xiao, Feng Xu, Dian-Ying Liao, Li Xie, Jin Wang, Feng Luo   +7 more
doaj   +1 more source

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases

Nucleic Acids Research, 2023
Abstract Fork reversal is a conserved mechanism to prevent stalled replication forks from collapsing. Formation and protection of reversed forks are two crucial steps in ensuring fork integrity and stability. Five RAD51 paralogs, namely, RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, which share sequence and structural similarity to the ...
Chia-Lun Guh, Kai-Hang Lei, Yi-An Chen, Yi-Zhen Jiang, Hao-Yen Chang, Hungjiun Liaw, Hung-Wen Li, Hsin-Yung Yen, Peter Chi   +8 more
openaire   +2 more sources

Rad51-GFP forms multiple foci in response to multiple DSBs.

, 2019
A) Representative images from strain DW106 expressing endogenous Rad51-eGFP and Rad52-RFP 3 h after HO induction. Magnification of white-boxed nucleus shown to the right. Maximum projection of 10–12 z-stack images every 0.5 μm. Scale bar = 5 μm. B) Rad51-
Allison Mazzella (6416615), Felix Zhou (3836689), Michael Tsabar (682400), Vinay V. Eapen (248199), Kevin Li (797705), James E. Haber (248202), Cheng-Sheng Lee (327161), David P. Waterman (6416612)   +7 more
core   +1 more source

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. [PDF]

, 2010
Homologous recombination mediated by RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-strand breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and PALB2 act together to deliver
Saro, Dorina, Eloïse Dray, Vitold E Galkin, Gareth J Williams, Chen, Junjie, Williams, GJ, Tsai, MS, Egelman, Edward, Dray, E, Miaw-Sheue Tsai, Schild, D., Claudia Wiese, Schild, D, Vitold E. Galkin, Hammel, M, Wiese, Claudia, D. Schild, David Schild, Yu, X, Schild, David, Egelman, E, Julia Etchin, Shirley M-H Sy, Edward Egelman, Xiong Yu, Galkin, Vitold E., wiese, C, Sung, P, Sy, Shirley M-H, Liu, Dongqing, Junjie Chen, Chen, J, Galkin, VE, Williams, Gareth J., Hammel, Michal, Dorina Saro, Michal Hammel, Dray, Eloise, Tsai, Miaw-Sheue, Saro, D, Sung, Patrick, Etchin, J, Patrick Sung, Gareth J. Williams, Etchin, Julia, Williams, Gareth J, Yu, Xiong, Sy, SMH, Sy, Shirley M-H., Galkin, Vitold E, Liu, D, Dongqing Liu, Shirley M-H. Sy   +52 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Rad51-GFP forms a DSB-dependent focus.

, 2019
A) Representative images of strain DW58 expressing Rad51-eGFP 6 h after HO induction. Magnification of white boxed nucleus shown to the right. Maximum projection of 10 z-stack images every 0.5 μm. Scale bar = 5 μm. B) Representative images of strain DW88
Allison Mazzella (6416615), Felix Zhou (3836689), Michael Tsabar (682400), Vinay V. Eapen (248199), Kevin Li (797705), James E. Haber (248202), Cheng-Sheng Lee (327161), David P. Waterman (6416612)   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The impact of RAD51 protein on the sensitivity of ovarian cancer to neoadjuvant chemotherapy [PDF]

精准医学杂志
Objective To investigate the impact of RAD51 protein on the sensitivity of ovarian cancer to neoadjuvant chemotherapy (NACT). Methods Tumor biopsy tissue samples were collected before NACT from 47 patients with advanced high-grade serous ovarian cancer ...
LIU Hui, CHEN Yunqing, QI Huiyang, SUN Xin, LOU Yanhui
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair

Cancer Management and Research, 2020
Songwei Huan,1,* Tao Gui,1,* Qiutong Xu,1,* Songkuan Zhuang,2 Zhenyan Li,1 Yuling Shi,3 Jiebin Lin,3 Bin Gong,1 Guiqiang Miao,1 Manseng Tam,4 Huan-Tian Zhang,1 Zhengang Zha,1 Chunfei Wu3 1Institute of Orthopedic Diseases and Department of Bone and Joint ...
Huan S, Gui T, Xu Q, Zhuang S, Li Z, Shi Y, Lin J, Gong B, Miao G, Tam M, Zhang HT, Zha Z, Wu C   +12 more
doaj