Results 61 to 70 of about 35,752 (235)

Regulation of Rad51 function by phosphorylation

The EMBO Reports, 2011
Rad51 is a key enzyme involved in DNA double-strand break repair by homologous recombination. Here, we show that in response to DNA damage, budding yeast Rad51 is phosphorylated on Ser 192 in a manner that is primarily mediated by the DNA-damage-responsive protein kinase Mec1.
Sonja Flott, Youngho Kwon, Ying Zhang Pigli, Phoebe A Rice, Patrick Sung, Stephen P Jackson   +5 more
openaire   +3 more sources

Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer

EMBO Molecular Medicine, 2021
Early relapse after platinum chemotherapy in epithelial ovarian cancer (EOC) portends poor survival. A‐priori identification of platinum resistance is therefore crucial to improve on standard first‐line carboplatin–paclitaxel treatment.
Michal M Hoppe, Patrick Jaynes, Joanna D Wardyn, Sai Srinivas Upadhyayula, Tuan Zea Tan, Stefanus Lie, Diana G Z Lim, Brendan N K Pang, Sherlly Lim, Joe P S Yeong, Anthony Karnezis, Derek S Chiu, Samuel Leung, David G Huntsman, Anna S Sedukhina, Ko Sato, Monique D Topp, Clare L Scott, Hyungwon Choi, Naina R Patel, Robert Brown, Stan B Kaye, Jason J Pitt, David S P Tan, Anand D Jeyasekharan   +24 more
doaj   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

RAD51, BRCA1, and BRCA2: Can be Promising Prognostic Factors and New Therapy Targets for Clear Cell Renal Cell Carcinoma Patients?

Journal of Urological Surgery
Objective: Clear cell renal cell carcinoma (ccRCC) is the predominant form of renal cell carcinoma, distinguished by its genetic alterations that affects the tumor’s progression and response to treatment.
Amira M. Abd El Maged, Heba Mahmoud Abdelgeleel, Eslam G. Abozaid, Amira H Hanna, Hanan Lotfy Mohammed   +4 more
doaj   +1 more source

RAD51 expression and prognostic impact in patients with stomach adenocarcinoma [PDF]

PeerJ
Background Stomach adenocarcinoma (STAD) is the most common gastrointestinal cancer. A clear diagnosis and molecular targeted therapy have important implications for prolonging survival of patients.
Baiyu Jian, Hao Zhang, Li Fan, Yang Li, Nan Wu, Ningning Wang, Lingmin Li, Xueyan Li, Pengling Ge, Yingcai Niu, Jicheng Liu   +10 more
doaj   +2 more sources

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

METTL3 Increases Temozolomide Resistance in MGMT-Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m⁶A-IGF2BP2-Dependent Manner. [PDF]

CNS Neurosci Ther
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Deng H, Chen R, Qu D, Qu C, Shi J.
europepmc   +2 more sources

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

The Molecular Perspective: RAD51 and BRCA2 [PDF]

STEM CELLS, 2005
Learning Objectives After completing this course, the reader will be able to: Discuss homologous recombination and its role in cancer. Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com
openaire   +3 more sources

Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma

Analytical Cellular Pathology, 2020
Purpose. To examine the expression of RAD51 in oral squamous cell carcinoma (OSCC) and analyze its connection with pathological grade, clinical stage, and lymphatic metastasis potential. Methods. For this study, 74 OSCC samples, 15 normal mucosa tissues,
Yuyang Li, Jia Li, Jingchun Sun, Yingkun Liu, Dingkun Liu, Liuyi Du, Bizhou Wang, Weiwei Liu   +7 more
doaj   +1 more source