Results 51 to 60 of about 35,752 (235)

Expression and Prognostic Value of RAD51 in Adenocarcinoma at the Gastroesophageal Junction

Iranian Journal of Public Health, 2022
Background: The RAD51 recombinase is involved in homologous recombination and DNA repair. However, the association of RAD51 with the prognosis of adenocarcinoma at the gastroesophageal junction (ACGEJ) is not clear.
Darebai Redati, Xinhui Yang, Cheng Lei, Lin Liu, Lei Ge, Haijiang Wang   +5 more
doaj  

RADX Modulates RAD51 Activity to Control Replication Fork Protection

Cell Reports, 2018
Summary: RAD51 promotes homologous recombination repair (HR) of double-strand breaks and acts during DNA replication to facilitate fork reversal and protect nascent DNA strands from nuclease digestion.
Kamakoti P. Bhat, Archana Krishnamoorthy, Huzefa Dungrawala, Edwige B. Garcin, Mauro Modesti, David Cortez   +5 more
doaj   +1 more source

C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair

Cell Reports, 2023
Summary: The recombinase RAD51 plays a core role in DNA repair by homologous recombination (HR). The assembly and disassembly of RAD51 filament need to be orderly regulated by mediators such as BRCA2 and anti-recombinases.
Zenan Zhou, Han Yang, Xinxin Liang, Tao Zhou, Tao Zhang, Yang Yang, Jiadong Wang, Weibin Wang   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Rad51-GFP is not dominant negative.

, 2019
A) Schematic of repair by gene conversion in YJK17. An HO-induced DSB made on chromosome III is repaired by the MATa-inc donor sequence on chromosome V, which contains a mutation (-inc) that prevents further cutting.
Allison Mazzella (6416615), Felix Zhou (3836689), Michael Tsabar (682400), Vinay V. Eapen (248199), Kevin Li (797705), James E. Haber (248202), Cheng-Sheng Lee (327161), David P. Waterman (6416612)   +7 more
core   +1 more source

E2F1-regulated long non-coding RNA RAD51-AS1 promotes cell cycle progression, inhibits apoptosis and predicts poor prognosis in epithelial ovarian cancer

Scientific Reports, 2017
Long non-coding RNA RAD51 antisense RNA 1 (RAD51-AS1, also known as TODRA) has been shown to be down-regulated by E2F1, a key cell cycle and apoptosis regulator, in breast cancer. Little is known regarding the role of RAD51-AS1 in disease.
Xiaodan Zhang, Guoping Liu, Junjun Qiu, Ning Zhang, Jingxin Ding, Keqin Hua   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Swi5–Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance In DNA homologous recombination, recombinase-coated single-stranded DNA filament formation is the first committed step and is subject to tight regulation. Stabilization of nucleoprotein filament by accessory proteins can be achieved by enhancing filament formation, reducing filament disassembly, or both.
Chih-Hao Lu, Hsin-Yi Yeh, Guan-Chin Su, Kentaro Ito, Yumiko Kurokawa, Hiroshi Iwasaki, Peter Chi, Hung-Wen Li   +7 more
openaire   +2 more sources

Rad51 supports triple negative breast cancer metastasis [PDF]

, 2014
In contrast to extensive studies on familial breast cancer, it is currently unclear whether defects in DNA double strand break (DSB) repair genes play a role in sporadic breast cancer development and progression.
Khanna, KK, Simpson, Peter T., Anderson, Robin, Gorski, Julia J., Bolderson, E, Al-Ejeh, Fares, Yap, PY, Lakhani, Sunil R., Bolderson, Emma, Chenevix-Trench, Georgia, Da Silva, Leonard, Yap, Pei Yi, Yap, Pei-Yi, Al-Ejeh, F, Chee, N, Chenevix-Trench, G, Wiegmans, Adrian P., Lakhani, SR, Chee, Nicole, Khanna, Kum Kum, Da Silva, L, Gorski, JJ, Anderson, R, Simpson, PT, Wiegmans, AP   +24 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source