Results 31 to 40 of about 27,541 (198)
BRCA1-BARD1: the importance of being in shape
Molecular & Cellular Oncology, 2019 The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation.
Manuel Daza-Martin +2 more
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Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
Nature Communications, 2023 The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the DNA-strand exchange RAD51 protein in homology-directed repair.
Robert Appleby +3 more
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Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation [PDF]
Nature, 2011 Homologous recombination is a high-fidelity DNA repair pathway. Besides a critical role in accurate chromosome segregation during meiosis, recombination functions in DNA repair and in the recovery of stalled or broken replication forks to ensure genomic stability.
Liu, Jie +5 more
openaire +6 more sources
G3: Genes, Genomes, Genetics, 2019 Candida albicans, the most common fungal pathogen, is a diploid with a genome that is rich in repeats and has high levels of heterozygosity. To study the role of different recombination pathways on direct-repeat recombination, we replaced either allele ...
Alberto Bellido +5 more
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Cancer Cell International, 2023 Objectives RAD51 overexpression has been reported to serve as a marker of poor prognosis in several cancer types. This study aimed to survey the role of RAD51 in oral squamous cell carcinoma and whether RAD51 could be a potential therapeutic target ...
Yu-Fen Tsai +6 more
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Molecular Determinant of DIDS Analogs Targeting RAD51 Activity
Molecules, 2021 RAD51 is the central protein in DNA repair by homologous recombination (HR), involved in several steps of this process. It is shown that overexpression of the RAD51 protein is correlated with increased survival of cancer cells to cancer treatments.
Denis Velic +6 more
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RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
Nucleic Acids Research, 2023 Abstract Fork reversal is a conserved mechanism to prevent stalled replication forks from collapsing. Formation and protection of reversed forks are two crucial steps in ensuring fork integrity and stability. Five RAD51 paralogs, namely, RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, which share sequence and structural similarity to the ...
Chia-Lun Guh +8 more
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Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function [PDF]
Nature Communications, 2021 AbstractThe RAD51 recombinase assembles as helical nucleoprotein filaments on single-stranded DNA (ssDNA) and mediates invasion and strand exchange with homologous duplex DNA (dsDNA) during homologous recombination (HR), as well as protection and restart of stalled replication forks.
Mário Špírek +4 more
openaire +3 more sources
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. [PDF]
PLoS ONE, 2017 BACKGROUND:Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined.
Yan Li +7 more
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Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
International Journal of General Medicine, 2022 Yaqin Shi,1,* Meng Shen,1,* Mengdan Xu,1 Min Tao,1 Kai Chen,1 Qingqing Zhu2 1Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Respiratory Medicine, The First ...
Shi Y +5 more
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