Results 81 to 90 of about 35,752 (235)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Prostate cancer remains a leading cause of cancer‐related mortality, largely driven by progression to metastatic castration‐resistant prostate cancer (mCRPC). Although poly(ADP‐ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR) alterations, particularly in BRCA2‐mutated disease,
Jhen‐Hao Jhan +4 more
wiley +1 more source
Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics [PDF]
Nucleic Acids Research, 2007 Rad51 and Rad54 are key proteins that collaborate during homologous recombination. Rad51 forms a presynaptic filament with ATP and ssDNA active in homology search and DNA strand exchange, but the precise role of its ATPase activity is poorly understood.
Li, Xuan +6 more
openaire +4 more sources
SkinDB: A Curated Resource for Dermatological Data Warehousing and Bioinformatics Exploration
Med Research, EarlyView.SkinDB is an open‐access transcriptomic database integrating 220 datasets and 11,283 samples across six major skin diseases. Its code‐free interface supports cross‐disease analyses, visualizations, and data downloads for dermatological research. ABSTRACT Dermatology lacks a centralized analysis‐ready transcriptomic resource, leaving publicly available ...
Haoxue Zhang +8 more
wiley +1 more source
, 2016 A. Illustration of single-molecule RAD51-ssDNA filament assay with partial DNA duplex containing a 30—nucleotide tail. Upon RAD51 filament formation, there is a transition from high FRET (DNA-only) to low FRET (RAD51-bound). B. Histograms display a clear
Ryan B. Jensen (2937867) +6 more
core +1 more source
The Anticancer Effect of RAD51-IN-1 in MDAH-2774 (CVCL_0420) Cells [PDF]
Biotechnologia ActaAim. This study aimed to investigate the effect of pharmacological inhibition of RAD51, via RAD51-IN-1, on the MDAH-2774 cell line. Methods. To achieve these objectives, firstly, MDAH-2774 cells were treated with different doses of RAD51-IN-1 to ...
Deniz ÖZDEMİR, Can Ali AĞCA
doaj +1 more source
Rad51 catalytic mutants differentially affect the Rad51 nucleoprotein filament in vivo [PDF]
, 2016 ABSTRACT In this study, we utilized mouse hybridoma cell lines stably expressing ectopic wild-type Rad51, or the Rad51-K133A and Rad51-K133R catalytic mutants deficient in ATP binding and ATP hydrolysis, respectively, to investigate effects on the Rad51 nucleoprotein filament in vivo
Mundia, Maureen M. +2 more
openaire +1 more source
SMALL MOLECULES INHIBITORS OF RAD51 [PDF]
, 2023 Embodiments concern methods and small molecule compositions for selectively inhibiting RAD51-mediated D-loop formation while preserving RAD51's ability to form nucleoprotein filaments.
core +2 more sources
The Prostate, EarlyView.ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi).
Lorena Incorvaia +37 more
wiley +1 more source
Rad51 Interacts with Non-structural 3 Protein of Hepatitis C Virus and Regulates Viral Production
Frontiers in Microbiology, 2017 Hepatitis C virus (HCV) is a leading cause of chronic liver disease affecting over 170 million people worldwide. Chronic infection with HCV progresses to liver fibrosis, cirrhosis, and hepatocellular carcinoma.
Kidong Son +13 more
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao +3 more
wiley +1 more source