Results 101 to 110 of about 27,541 (198)

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Effects of Rad51 on Survival of A549 Cells

Asian Pacific Journal of Cancer Prevention, 2015
Rad51, a key factor in the homologous recombination pathway for the DNA double-strand break repair, plays a vital role in genesis of non-small-cell lung cancer (NSCLC). In recent years, more and more studies indicate that high expression of Rad51 is of great relevance to resistance of NSCLC to chemotherapeutic agents and ionizing radiation.
Sha-Sha, Yu, Yi, Tu, Lin-Lin, Xu, Xue-Qin, Tao, Shan, Xu, Shan-Shan, Wang, Yi-Feng, Xiong, Jin-Hong, Mei   +7 more
openaire   +3 more sources

Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma

Discover Oncology
Background Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral cavity, with over 70% of cases detected in advanced stages and a 5-year survival rate of 50%.
Yu-Xing Tang, Yu-Yan Pang, Yan Cui, Guo-Jiao Wu, Lin-Qing Huang, Chang-Zhan Zhou, Bin Li, Qi Li, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Jian-Di Li, Gang Chen, Dong-Ming Li, Yi-Wu Dang   +14 more
doaj   +1 more source

Homologous recombination mutants cause differing lethality between h− and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin

The FEBS Journal, EarlyView.
Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar, Siarhei Paliavoi, Barbora Stefanovie, Jan Josef Palecek   +3 more
wiley   +1 more source

Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis

Stem Cells International, 2018
Cervical cancer is the second most frequent tumor type in women worldwide with cases developing clinical recurrence, metastasis, and chemoresistance. The cancer stem cells (CSC) may be implicated in tumor resistance to therapy.
Graciela Ruíz, Heriberto A. Valencia-González, Ismael León-Galicia, Enrique García-Villa, Alejandro García-Carrancá, Patricio Gariglio   +5 more
doaj   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis

Discover Oncology
Objective Radiotherapy is a first-line treatment for nasopharyngeal carcinoma (NPC), but resistance to radiation remains a major clinical challenge. This study aimed to investigate the role of RAD51, a key homologous recombination repair protein, in ...
Fuchuan Xie, Jian Song, Yunming Tian, Xinyu Zhang, Tanhuan Chen, Meng Xu   +5 more
doaj   +1 more source

RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer

Cancer Cell International, 2019
Background The DNA damage and repair pathway is considered a promising target for developing strategies against cancer. RAD51, also known as RECA, is a recombinase that performs the critical step in homologous recombination.
Xiaomeng Zhang, Ningyi Ma, Weiqiang Yao, Shuo Li, Zhigang Ren   +4 more
doaj   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

ATXR5 and ATXR6 restrict meiotic crossover formation within heterochromatin in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis H3K27 mono‐methyltransferases ATXR5 and ATXR6 repress crossovers within meiotic heterochromatin, are required for heterochromatin condensation and H3K27me1 establishment, and specifically influence the maintenance of DNA methylation in meiocytes.
Jun Zhang, Yue Yu, Han Wang, Meiling Li, Dingning Li, Chenjiang You, Yingxiang Wang, Cong Wang   +7 more
wiley   +1 more source