Results 121 to 130 of about 35,752 (235)

Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity

BioEssays, Volume 48, Issue 10, October 2026.
The dynamics of PML body formation at telomeres in cancer cells using the alternative lengthening of telomeres (ALT) pathway for telomere elongation correlate with different degrees of ALT activity and might contribute to telomere length heterogeneity in ALT cancer cells.
Huaiying Zhang
wiley   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, Volume 101, Issue 5, Page 2265-2278, October 2026.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

RAD51-GFP restores fertility of the Arabidopsis rad51 mutant.

, 2013
(A) Schematic representation of the RAD51-GFP fusion construct. (B) Wild-type plants have long siliques full of seeds, while rad51 mutants are completely sterile. Expression of RAD51-GFP in rad51 mutants restores fertility.
Simon Amiard (463292), Fabienne Degroote (463291), Olivier Da Ines (169710), Chantal Goubely (169719), Charles I. White (169736), Maria E. Gallego (463293)   +5 more
core   +1 more source

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan, Siyi Liu, Yanling Li, Qian He, Chen Long, Ning Tang, Yanhong Zhou   +6 more
wiley   +1 more source

Artificial Intelligence in Gastric Cancer: Diagnostic, Prognostic, and Predictive Developments, Evidence Maturity, and Translational Challenges

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) remains a major global health burden characterized by substantial heterogeneity in diagnosis, prognosis, and treatment response. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has been increasingly investigated for the analysis of endoscopic images, radiological scans, whole‐
Chong Chen, Weisong Xu, Tong Wu, Junpeng Zhao, Xuebing Xu, Mingbing Xiao, Kang Xu   +6 more
wiley   +1 more source

TbRMI1 is required for both RAD51-dependent and RAD51-independent VSG switching.

, 2013
(A) Simultaneous deletion of RMI1 and RAD51 severely impairs VSG switching. Overall VSG switching frequencies of wild type, rmi1, rad51, and rmi1 rad51 were plotted. (B) Increased VSG GC rate in rmi1 was dependent on RAD51, but RMI1 also functions in VSG
Hee-Sook Kim (246035), George A. M. Cross (10509)   +1 more
core   +1 more source

The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA

Nature Communications
Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs.
Sarah R. Hengel, Katherine G. Oppenheimer, Chelsea M. Smith, Matthew A. Schaich, Hayley L. Rein, Julieta Martino, Kristie E. Darrah, Maggie Witham, Oluchi C. Ezekwenna, Kyle R. Burton, Bennett Van Houten, Maria Spies, Kara A. Bernstein   +12 more
doaj   +1 more source

Clinical and Molecular Features of BAP1‐Mutated Meningiomas: Case Series

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1343-1350, October 2026.
ABSTRACT BRCA1‐associated protein 1 (BAP1)‐deficient meningiomas represent a clinically and molecularly distinct subgroup with variable histology and aggressive behavior that may not be fully captured by current grading criteria. The clinical spectrum of BAP1 alterations in meningiomas, including both somatic and germline contexts, remains incompletely
Ivan Pradilla, Rasha Alfattal, Susan L. McGovern, Shaan M. Raza, Franco DeMonte, Leomar Y. Ballester, Chirag B. Patel, Carlos Kamiya‐Matsuoka   +7 more
wiley   +1 more source

Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer

MedComm, Volume 7, Issue 10, October 2026.
Cooccurrence of dMMR and HRD in colorectal cancer. On the left blue shaded area, the dMMR (deficient mismatch repair) pathway is shown as a result of the loss of key DNA repair genes MLH1, MSH2, MSH6, and PMS2, which cause single strand breaks.
Xu Zhang, Hao Xu, Kailai Wang, Wangxiong Hu   +3 more
wiley   +1 more source

Rad51 paralogs remodel pre-synaptic Rad51 filaments to stimulate homologous recombination

, 2020
Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes strand exchange with homologous duplex DNA.
David Rueda (1310622), Raffaella Carzaniga (3220551), Kathy R Chaurasiya (9394256), Lucy M Collinson (8128938), Mário Špírek (9394253), Jordan D Ward (9394259), Martin RG Taylor (9394250), Lumir Krejci (252456), Edward H Egelman (9394262), Simon J Boulton (8274444), Xiong Yu (8735757)   +10 more
core