Results 111 to 120 of about 27,662 (214)

Mechanisms That Govern Recombinase Fidelity Control During Eukaryotic Homologous Recombination

BioEssays, Volume 48, Issue 8, August 2026.
The rate of recombinase filament formation controls the fidelity of the homologous recombination reaction by either restricting the length of strand pairing for high‐fidelity repair or increasing the length of strand pairing for more complex outcomes.
Ilayda Korkmaz, J. Brooks Crickard
wiley   +1 more source

Understanding risk perception and risk‐reducing decision‐making for surgery among individuals with a genetic predisposition to epithelial ovarian cancer

Journal of Genetic Counseling, Volume 35, Issue 4, August 2026.
Abstract Genetic predisposition to hereditary breast and ovarian cancer and Lynch syndrome increases the risk of developing cancer, including epithelial ovarian cancer (EOC). Depending on the pathogenic variant, (e.g., BRCA1 or PMS2) the risk of developing EOC ranges from approximately 3%–60%.
Rebekah Kukurudz‐Gorowski, Sylvia Horn, Pascal Lambert, Kim Serfas, Renée El‐Gabalawy, Alon David Altman, Kirk James McManus, Jessica Nicole Hartley, Mark William Nachtigal   +8 more
wiley   +1 more source

Adenovirus Vector‐Mediated In Vivo Knock‐in Treatment of Neonatal Phenylketonuria Mice Using Terminally Cleaved Donor DNA

The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.
We successfully developed a highly efficient knock‐in adenovirus vector, AxPah‐6g‐cut. This vector cleaves not only the genomic target site but also the terminus of the donor DNA in the vector. When this vector was intravenously administered twice to phenylketonuria (Pahenu2) mice together with a Cas9‐expressing vector, AxCBCas9, it resulted in the ...
Megumi Yamaji, Hirotaka Tabata, Mariko Nakamura, Ryoko Fuse, Tadashi Okada, Shun‐Ichi Ohba, Tomokazu Ohishi, Manabu Kawada, Izumu Saito, Shigeto Sato, Tomoko Nakanishi   +10 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Rad51 Recombinase and Recombination Mediators [PDF]

Journal of Biological Chemistry, 2003
Patrick, Sung, Lumir, Krejci, Stephen, Van Komen, Michael G, Sehorn   +3 more
openaire   +2 more sources

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

A Tale of Two Cell Lines: Characterization of Differential Efficacy of Small Molecule Drugs Cediranib and NU‐7441 on Primary Versus Metastatic Colorectal Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Colorectal cancer is recognized as one of the leading causes of cancer death amongst both sexes in the U.S. Despite rigorous screening, those diagnosed with colon cancer often face poor prognosis, and approximately 70% of affected patients will develop metastatic relapse. The investigation of colon carcinoma cell lines' genetic variability and
Josephine D. Tsang, Cai M. Roberts
wiley   +1 more source

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, Volume 117, Issue 8, Page 2085-2097, August 2026.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

HDAC2‐Mediated SMAD7 Stabilisation Activates Wnt/β‐Catenin Signalling to Drive DNA Damage Repair and Cisplatin Resistance in Ovarian Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT To investigate the role of histone deacetylase 2 (HDAC2) in cisplatin resistance in ovarian cancer (OC). Cisplatin‐resistant OC cell lines were employed to construct HDAC2 overexpression and knockdown models, and their effects on cell proliferation and apoptosis were examined.
Yingying He, Meiling Wu, Xiaomin Xu, Kang Zheng, Kening Zhou   +4 more
wiley   +1 more source

Cancer mutations in RAD51 and its paralogues. [PDF]

PLoS One
Valentine AL, Huth IL, Duff NM, Rabbani AZ, Donahue KN, Bush WA, Bouley RA, Petreaca RC.   +7 more
europepmc   +1 more source