Results 131 to 140 of about 35,752 (235)

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

RAD51 homolog (RAD51) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Chronic Cigarette Smoke Extract Exposure Promotes Genomic and Phenotypic Reprogramming in Lung Cancer Cells

Thoracic Cancer, Volume 17, Issue 19, October 2026.
Chronic cigarette smoke extract exposure promoted genomic and phenotypic reprogramming in established lung cancer cells. Clonogenicity, migration, and tumor growth increased, accompanied by changes consistent with partial epithelial–mesenchymal transition. Transcriptomic analysis and whole‐genome sequencing revealed activation of inflammatory signaling,
Hyun Soo Kim, Se‐Eun Choi, In Kyoung Kim, Seulbee Lee, Seo‐Hee You, Rachel Hyunkyung Kim, Chang Dong Yeo, Jin‐A Kim, Seok Chung, Sang Haak Lee, Semin Lee, Hye Joung Kim   +11 more
wiley   +1 more source

NTAQ1 Promotes Hepatocellular Carcinoma Growth by Facilitating the Protein Degradation of the Tumor Suppressor PRDM2

Cancer Science, Volume 117, Issue 10, Page 2803-2818, October 2026.
Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Masahiro Hashimoto, Yusuke Nakano, Katsushi Dairaku, Yuya Ono, Yuki Miyata, Chihiro Matsumoto, Takanari Tatsumi, Satoshi Higuchi, Takashi Ofuchi, Akinori Tsujimoto, Yuki Ando, Qingjiang Hu, Yusuke Yonemura, Akira Shimizu, Takaaki Masuda, Yuji Soejima, Koshi Mimori   +21 more
wiley   +1 more source

BRCA2 BRC motifs bind RAD51-DNA filaments

, 2005
Germ-line mutations in BRCA2 account for approximately half the cases of autosomal dominant familial breast cancers. BRCA2 has been shown to interact directly with RAD51, an essential component of the cellular machinery for homologous recombination and ...
Yang, SX, Yang, S, West, SC, Galkin, VE, Yu, X, Egelman, EH, Esashi, Fumiko, Esashi, F   +7 more
core   +1 more source

Machine Learning‐Guided Identification of Madecassoside as a Potential RAD51 Modulator That Sensitizes Breast Cancer Cells to Cisplatin

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Madecassoside was selected from an in‐house natural product library through machine learning‐based virtual screening and identified as a potential modulator of RAD51‐mediated DNA repair that enhances cisplatin sensitivity in breast cancer cells. ABSTRACT Homologous recombination (HR) is an essential pathway for preserving the genomic stability of cells
Minju Oh, Mi‐Young Jeong, Jiwon Choi
wiley   +1 more source

Absence of DMC1 in rad51 RAD51-GFP mutants leads to extensive chromosome fragmentation.

, 2013
Meiotic spreads of PMCs showing ten intact univalents in dmc1 mutants (A), strong chromosome fragmentation in rad51 mutants (B) and five normal bivalents in rad51 RAD51-GFP mutants (C).
Simon Amiard (463292), Fabienne Degroote (463291), Olivier Da Ines (169710), Chantal Goubely (169719), Charles I. White (169736), Maria E. Gallego (463293)   +5 more
core   +1 more source

RAD51 as a Therapeutic Target and Predictive Biomarker in Breast Cancer Radiotherapy: A Systematic Review and Translational Synthesis

Babcock University Medical Journal
Background: Treatment-resistant breast cancer (BC) is a significant clinical issue. The prognostic and predictive value of RAD51 expression in BC and radiotherapy (RT) remains inconsistent.
Haael Abbas, Ali Mahdi, Nihad Tektook
doaj   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, Volume 59, Issue 10, October 2026.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Comparative Transcriptomic Analysis of In Vitro Matured Oocytes From Cyclic and Prepubertal Gilts Reveals Distinct Molecular Patterns

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT In vitro embryo production is a key tool in reproductive biotechnology, enabling genetic improvement, basic research on early development, and the generation of biomedical models. Despite high rates of nuclear maturation achieved during in vitro maturation (IVM) of porcine oocytes, inadequate cytoplasmic maturation continues to limit oocyte ...
Carolina G. Cabrera‐Gómez, David Gascón‐Collado, Paula Blanco‐Cueto, Belén Pequeño, Heriberto Rodríguez‐Martínez, Cristina A. Martínez‐Serrano   +5 more
wiley   +1 more source