Results 61 to 70 of about 35,845 (227)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Collective Trauma- Psychosocial consequences of war in northern Sri Lanka 10 years on, a mixed methods study

open access: yesSSM - Mental Health
Introduction: Individuals, families and communities in Sri Lanka, particularly in the North-East of Sri Lanka, have undergone 3 decades of war trauma. Methods: Mixed quantitative and qualitative methods with an integrated, holistic and inclusive approach
Umaharan Thamotharampillai   +7 more
doaj   +1 more source

Perspectives on Reconciliation & Indigenous Rights

open access: yesCosmopolitan Civil Societies: An Interdisciplinary Journal, 2009
This paper provides an overview of discourses of the movement for national reconciliation prevailing within the Australian socio-political context since the inception of the Council for Aboriginal Reconciliation in 1991, to the national apology delivered
Nina Burridge
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

High-Speed Reconciliation for CVQKD Based on Spatially Coupled LDPC Codes

open access: yesIEEE Photonics Journal, 2018
The speed of continuous variable quantum key distribution is limited by the reconciliation efficiency and the reconciliation frame error rate (FER) in the reconciliation phase.
Xue-Qin Jiang   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Prisvajanje javnega prostora na Primorskem med 1943 in 1945

open access: yesDileme
The article examines the processes of ideologically marked interventions in the public space of the Primorska region during the period from the capitulation of the Kingdom of Italy in September 1943 to the end of the Second World War in Europe.
Matic Batič
doaj   +1 more source

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