Results 61 to 70 of about 136,610 (287)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

National Centre for Reconciliation Practice Launch

, 2022
The National Centre for Reconciliation Practice (NCRP) will advance national industry, community and academic understandings of reconciliation and strongly contribute to national systemic change.
Professor Pascale Quester, Dr Jackie Huggins AM, Professor Andrew Gunstone, Melinda Cilento, Professor John Evans, Ian Hamm   +5 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The German Occupier's Efforts to Germanize and Nazify Slovenian Youth in Gorenjska Through the School System [PDF]

Šolska Kronika
In the article, the author presents the efforts of the German authorities to Germanize Slovenian youth in Gorenjska through the German occupation school system during the German occupation from 1941 to 1945.
Damjan Hančič
doaj  

Place Name Reconciliation Guiding Visions and Principles

Parks Stewardship Forum
Place name reconciliation works to align the nation’s place name landscape with the nation’s ongoing progress toward the values of truth and justice. The emphasis of place name reconciliation is reform.
Subcommittee on Principles and Processes, Federal Advisory Committee on Reconciliation in Place Names
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

2022 Swinburne Annual Reconciliation Lecture - Truth, Understanding and Transformation

, 2022
Swinburne University of Technology and the National Centre for Reconciliation Practice is delighted to welcome Commissioner Sue-Anne Hunter, Deputy Chair Yoorrook Justice Commission, to deliver the 2022 Swinburne Annual Reconciliation Lecture on Thursday
Aunty Georgina Nicholson, Professor Pascale Quester, Professor Andrew Gunstone, Commissioner Sue-Anne Hunter   +3 more
core   +1 more source