Results 31 to 40 of about 22,424 (258)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Las nuevas formas de vivir en familia: el caso de las familias reconstituidas
Cuadernos de Relaciones Laborales, 2008 One of the features more visible in comparing the results of the (2001) last census in Spain with those of 1991 is the emergence of a new type of household structure: the reconstituted family composed by a couple with the children of a previous relation.
Ana Mª Rivas Rivas
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
An evaluation of the family reconstitution technique [PDF]
Scandinavian Economic History Review, 1977 Abstract When the family reconstitution technique was developed in the 1950s by M. Fleury and L. Henry it became possible to conduct statistical demographic analysis on material several centuries older than the first European censuses. This is a typical example of how until recently the exploitation of potentially valuable information was obstructed by
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Industrial Crops and ProductsWe combined bioinformatics and synthetic biology to identify key gene families involved cannabidiol (CBD) synthesis and reconstituted the complete CBD pathway in Nicotiana benthamiana.
Fu Wang +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Anthropologica, 2008 Llama la atención que autores como Théry (1985), Le Gall y Martin (1993) y Le Gall (1996) no hayan extraído, en sus estudios sobre las familias reconstituidas, todas las consecuencias posibles de la idea de constelación familiar, en especial la que ...
María Isabel Jociles Rubio +1 more
doaj
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source