Results 61 to 70 of about 686,607 (294)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Assessment and Comparison of Hospital Information Systems in Isfahan Hospitals based on the Adjusted DeLone and McLean Model

open access: yesمدیریت اطلاعات سلامت, 2011
Introduction: Hospital Information Systems (HISs) have positive effects on patients' treatment process and organizational function. Therefore, it is necessary to evaluate the quality of services provided by such systems.
Sakeineh Saghaeiannejad Isfahani   +3 more
doaj  

Kedudukan Kelembagaan dan Praktik Pengelolaan Arsip di Lingkungan Peguruan Tinggi: Studi Pada Universitas Gadjah Mada, Universitas Negeri Yogyakarta, dan Universitas Pembangunan Nasional Veteran Yogyakarta

open access: yesKhazanah: Jurnal Pengembangan Kearsipan, 2019
Tujuan penelitian ini adalah untuk menganalisis pelaksanaan records management dan archives administration di Universitas Gadjah Mada (UGM), Universitas Negeri Yogyakarta (UNY), dan Universitas Pembangunan Nasional Veteran Yogyakarta (UPN VY). Penelitian
Herman Setyawan   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Organizational Maturity Needs in Medical Record Departments of Isfahan Public Hospitals Based on People Capacity Maturity Model (PCMM)

open access: yesمدیریت اطلاعات سلامت, 2012
• Introduction: Today, many organizations attempt to fully develop in gradual evolution of their processes. PCMM is one of the models which focus on improving organizational human capabilities.
Farzaneh Hatampour   +3 more
doaj  

Współczesny zarządca dokumentacji a zarządzający aktami specjalista-organizator wg koncepcji Jana Kościołka

open access: yesArchiwa - Kancelarie - Zbiory, 2017
Historia zarządzania dokumentacją, a więc i droga dziejowa zawodu zarządcy dokumentacji zaczyna się znacznie wcześniej, niż ustalenie ram teoretycznych tej dyscypliny naukowej.
Marcin Smoczyński
doaj   +1 more source

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