Results 91 to 100 of about 3,916,352 (384)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Association Between Early Cognitive Impairment and Midterm Functional Outcomes Among Chinese Acute Ischemic Stroke Patients: A Longitudinal Study

Frontiers in Neurology, 2020
Background: Cognitive decline is common after stroke. The influence of early cognitive impairment on midterm functional outcomes among Chinese acute ischemic stroke (AIS) patients has not been fully studied.
Juan Li, Jing Wang, Bei Wu, Hanzhang Xu, Hanzhang Xu, Xiongfeng Wu, Lanshu Zhou, Benqiang Deng   +7 more
doaj   +1 more source

Recovery of Olfactory Function Induces Neuroplasticity Effects in Patients with Smell Loss

Journal of Neural Transplantation and Plasticity, 2014
The plasticity of brain function, especially reorganization after stroke or sensory loss, has been investigated extensively. Based upon its special characteristics, the olfactory system allows the investigation of functional networks in patients with ...
K. Kollndorfer, Ksenia Kowalczyk, Elisabeth Hoche, C. Mueller, M. Pollak, S. Trattnig, V. Schöpf   +6 more
semanticscholar   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Relationship Between Performance Improvement in Activities of Daily Living and Energy Intake in Older Patients With Hip Fracture Undergoing Rehabilitation [PDF]

Annals of Rehabilitation Medicine, 2019
Objective To analyze whether sufficient energy intake (EI) improves performance of activities of daily living (ADL) in patients with hip fracture admitted to rehabilitation hospitals. The adequate amount of EI for improving performance of ADL in patients
Hiroki Umezawa, Yoji Kokura, Satoko Abe, Chieko Suzuki, Akiko Nishida, Yoshie Uchiyama, Keisuke Maeda, Hidetaka Wakabayashi, Ryo Momosaki   +8 more
doaj   +1 more source

Resilience-based performance modeling and decision optimization for transportation network [PDF]

arXiv, 2018
This research presented a novel resilience-based framework to support resilience planning regarding pre-disaster mitigation and post-disaster recovery. First, the author proposes a new performance metric for transportation network, weighted number of independent pathways (WIPW), integrating the network topology, redundancy level, traffic patterns ...
arxiv  

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Optimal recovery of convolutions of $n$ functions according to linear information [PDF]

arXiv, 2015
We found the optimal linear information and the optimal method of its use to recovery of the convolution of n functions on some classes of $2\pi$ - periodic functions.
arxiv  

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Recovery of 𝐻^{𝑝}-functions [PDF]

Proceedings of the American Mathematical Society, 1984
Let there be given finitely many points { α k } 1 n \{ {\alpha _k}\} _1^n from the unit disc. If f f is a H p {H^p} -function then how well can the value of
openaire   +2 more sources