Results 71 to 80 of about 4,085,402 (300)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Battery-Friendly Relay Selection Scheme for Prolonging the Lifetimes of Sensor Nodes in the Internet of Things

IEEE Access, 2019
The Internet of Things (IoT) is an important part of the new generation of information technology. It utilizes many sensor nodes to collect data and monitor the environment and can be applied in various fields. However, because the energy of sensor nodes
Jin Li, Wei Liu, Tian Wang, Houbing Song, Xiong Li, Fang Liu, Anfeng Liu   +6 more
doaj   +1 more source

Blood lactate clearance during active recovery after an intense running bout depends on the intensity of the active recovery [PDF]

, 2010
High-intensity exercise training contributes to the production and accumulation of blood lactate, which is cleared by active recovery. However, there is no commonly agreed intensity or mode for clearing accumulated blood lactate.
Kemi, O.J., McIntyre, L., Menzies, C., Menzies, P., Paterson, P., Wilson, J.   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Jointly Sparse Support Recovery via Deep Auto-encoder with Applications in MIMO-based Grant-Free Random Access for mMTC

, 2020
In this paper, a data-driven approach is proposed to jointly design the common sensing (measurement) matrix and jointly support recovery method for complex signals, using a standard deep auto-encoder for real numbers.
Cui, Ying, Li, Shuaichao, Zhang, Wanqing
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis and Evaluation of Control Action End-State Impact on Manufacturing System Future Production

IEEE Access, 2018
Some control actions (e.g., scheduling overtime production during breaks to catch up throughput) in a serial production line will drive the system to different states at the end time of the actions (defined as the action end-state), and influence the ...
Jing Zou, Qing Chang, Jorge Arinez, Guoxian Xiao   +3 more
doaj   +1 more source

Recovery of bilevel causal signals with finite rate of innovation using positive sampling kernels [PDF]

, 2013
Bilevel signal $x$ with maximal local rate of innovation $R$ is a continuous-time signal that takes only two values 0 and 1 and that there is at most one transition position in any time period of 1/R.In this note, we introduce a recovery method for ...
Atallah, Elie, Ramesh, Gayatri, Sun, Qiyu   +2 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source