Results 71 to 80 of about 17,118,890 (293)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Comparison of post-activation performance enhancement in the lower limbs of short sprinters based on two velocity loss thresholds

Frontiers in Sports and Active Living
ObjectiveThe present study examined the effects of post-activation performance enhancement (PAPE) induced by different velocity loss (VL) thresholds on lower-limb explosive performance in sprinters under velocity-based resistance training (VBT).
Xiaohan Wang, Xiaohan Wang, Sidan Lu, Sidan Lu, Xinsong Cheng, Xinsong Cheng, Junjie He, Junjie He, Jianheng Wei, Jianheng Wei, Qihao Sun, Qihao Sun, Tian Zhou, Tian Zhou, Yin Yu, Yin Yu   +15 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Performance-Based Seismic Loss and Recovery Assessment of Residential Buildings in Bucharest Using FEMA P-58 and SP3: Implications for Seismic Resilience

Applied Sciences
This study presents a probabilistic assessment of seismic loss and recovery for residential buildings in Bucharest, Romania, using the FEMA P-58 framework implemented in SP3.
Bogdan Gheorghe, Radu Vacareanu
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Influence of Shunt Branch on the Current Limiting and Recovery Performance of Variable Resistance SFCL

IEEE Access
With the continuous development of power grid, the high short-circuit threatens the stability of the power system. The short-circuit exceeds the disconnection capacity of the circuit breaker and has a negative impact on the integrity and stability of the
Duanjiao Li, Bin Xiang, Congwei Yao, Qi Zhang, Xiaofeng Pang, Wenxing Sun, Haiyun Tang, Xue Zhang, Zhongbin Yuan, Linglong Cai   +9 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Early vs late ICU admission in patients with COVID-19 pneumonia

Journal of Infection in Developing Countries
Introduction: The type of admission to the Intensive Care Unit (ICU) influences the prognosis of patients with severe pneumonia and, in the case of patients with COVID-19 pneumonia, this is still unexplored.
Miguel Alejandro Pinzón, Santiago Ortiz, Henry Laniado, Nelson Javier Fonseca-Ruiz, Juan Felipe Betancur, Héctor Holguín, Pablo Montoya, Bernardo Javier Muñoz, Beatriz Ramírez, Carolina Arias Arias, Isabel Potes, Luz Maribel Toro, Julian Quiceno   +12 more
doaj   +1 more source