Results 111 to 120 of about 1,605,665 (319)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Cost analysis of the University of Wisconsin-Stout unclassified recruitment and selection process [PDF]
, 2003 Plan BThe purpose of this research was to determine a baseline for the costs of the University of Wisconsin – Stout’s unclassified recruitment and selection process, and to examine the efficacy of these costs in attracting an adequate number of ...
LeCompte, Angela D.
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A systematic review of models to predict recruitment to multicentre clinical trials
, 2010 Background Less than one third of publicly funded trials managed to recruit according to their original plan often resulting in request for additional funding and/or time extensions.
Barnard Katharine D +8 more
core +1 more source
Scientia Marina, 2004 Young-of-the-year European hake (Merluccius merluccius) were sampled during four seasonal cruises between November 1998 and September 1999. The greatest numbers and biomass were found in spring 1999.
Beatriz Morales-Nin, Joan Moranta
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Recruitment and retention [PDF]
British Dental Journal, 2020 I, Hussain, A, Thomson, T, Norfolk
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Measures for Ph.D. Evaluation: the Recruitment Process [PDF]
Recently the quality of Higher Education (HE) system and its evaluation have been key issues of the political and scientific debate on education policies all over Europe.
Giulio Ghellini +3 more
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