Results 71 to 80 of about 3,004,369 (336)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Tunneling nanotube-mediated stem cell immunomodulation dysfunction promotes adipose inflammation and insulin resistance in GDM

Cell Reports
Summary: Adipose-derived stem cells (ADSCs) represent a promising therapeutic resource, yet their immunometabolic regulation remains poorly defined. Here, we reveal a tunneling nanotube (TNT)-mediated communication mechanism between ADSCs and adipose ...
Bingnan Chen, Xuyang Chen, Jianxin Li, Ruohan Hu, Lijun Yang, Hongli Li, Xinmi Liu, Richard D. Cannon, Richard Saffery, Boris Novakovic, Hongbo Qi, Hua Zhang, Xiaobo Zhou   +12 more
doaj   +1 more source

Drosophila DNA-Binding Proteins in Polycomb Repression

Epigenomes, 2018
The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms.
Maksim Erokhin, Pavel Georgiev, Darya Chetverina   +2 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces

eLife, 2016
Tightly controlled recruitment of telomerase, a low-abundance enzyme, to telomeres is essential for regulated telomere synthesis. Recent studies in human cells revealed that a patch of amino acids in the shelterin component TPP1, called the TEL-patch, is
Xichan Hu, Jinqiang Liu, Hyun-IK Jun, Jin-Kwang Kim, Feng Qiao   +4 more
doaj   +1 more source

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation [PDF]

, 2018
The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early-onset Parkinson’s disease. Parkin is autoinhibited but is activated by the kinase PINK1 that phosphorylates ubiquitin leading to ...
Aguirre, Jacob D., Barber, Kathryn R., Chaugule, Viduth K., Condos, Tara E.C., Dunkerley, Karen M., Freeman, E Aisha, Konermann, Lars, Shaw, Gary S., Walden, Helen, Xiao, Yiming   +9 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Older people’s participation and engagement in falls prevention interventions: Comparing rates and settings [PDF]

, 2013
Objective: Falls among older people remain a major public health issue. The purpose of this article was to facilitate accurate interpretation of the existing evidence-base and facilitate robust planning of future fall prevention randomised controlled ...
Burleigh, Cameron, Cameron, Edwards, Flicker, Gillespie, Gillespie, Goodwin, Hagedorn, Healey, Hughes, Nyman, Nyman, Sihvonen, Tinetti, Vassallo, World Health Organization   +16 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Flat oyster fishery management during a time with fluctuating population size

Aquatic Living Resources, 2019
Wild populations of the native European flat oyster (Ostrea edulis) are nowadays rare. Worldwide, flat oyster populations have declined due to overexploitation, diseases and pollution. Yet, in the Limfjorden, Denmark, a small but persistent population of
Nielsen Pernille, Petersen Jens Kjerulf
doaj   +1 more source