Results 41 to 50 of about 449,476 (220)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Do recruitment maneuvers simply improve oxygenation?

, 2010
Recruitment maneuvers have been the subject of intense investigation. Their role in the acute care setting is debated given the lack of information on their influence on clinical outcomes. Oxygenation improvement is often a striking effect, together with
F. Valenza, Franco Valenza
core   +1 more source

Pulmonar recruitment in acute respiratory distress syndrome. What is the best strategy?

Revista do Colégio Brasileiro de Cirurgiões
Supporting patients with acute respiratory distress syndrome (ARDS), using a protective mechanical ventilation strategy characterized by low tidal volume and limitation of positive end-expiratory pressure (PEEP) is a standard practice in the intensive ...
Cíntia Lourenço Santos, Cynthia dos Santos Samary, Pedro Laurindo Fiorio Júnior, Bruna Lourenço Santos, Alberto Schanaider   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Alveolar recruitment maneuvers in the control of lung atelectasis

, 2022
Resumen: El colapso parcial o total del pulmón o un lóbulo pulmonar denominado atelectasia es una de las principales complicaciones en los pacientes asistidos con ventilación mecánica en la unidad de cuidados intensivos y en el periodo perioperatorio ...
Rondón Barragán, Iang Schroniltgen, Ospina Argüelles, Diego Alejandro, Buriticá Gaviria, Edwin Fernando, Echeverry Bonilla, Diego Fernando, Villanueva Rodríguez, Cindy Libeth   +4 more
core   +1 more source

Effect of Chest Physiotherapy and Lung Recruitment Maneuvers on Hemodynamics of Mechanically Ventilated Patients with Lung Injuries: A Quasi-Experimental study [PDF]

Port Said Scientific Journal of Nursing
Background: Lung injury in mechanically ventilated patients often leads to impaired gas exchange, decreased lung compliance, and hemodynamic instability. Chest physiotherapy and lung recruitment maneuvers are common strategies to enhance airway clearance,
Remas Gabal
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Análisis de las maniobras de reclutamiento alveolar aplicadas en siete Unidades de Cuidado Intensivo

Revista Ciencias de la Salud, 2010
Introduction: For the past years, alveolar recruitment maneuvers (RM) have originated a growing interest due to their beneficial potential in pulmonary protection, and have been introduced in clinical practice.
Esther Cecilia Wilches-Luna, Diana Durán-Palomino, Vilma Eugenia Muñoz-Arcos   +2 more
doaj  

Associação das manobras de recrutamento alveolar e posição prona na síndrome do desconforto respiratório agudo Association of alveolar recruitment maneuvers and prone position in acute respiratory disease syndrome patients

Revista Brasileira de Terapia Intensiva, 2009
A síndrome do desconforto respiratório agudo é a apresentação clínica de insuficiência respiratória aguda caracterizada por lesão alveolar difusa e pelo desenvolvimento do edema pulmonar não cardiogênico, devido ao aumento da permeabilidade da membrana ...
Daniela Caetano Costa, Eduardo Rocha, Tatiane Flores Ribeiro   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source