Results 51 to 60 of about 449,476 (220)

Clinical review : The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury

, 2021
Mechanical ventilation can cause and perpetuate lung injury if alveolar overdistension, cyclic collapse, and reopening of alveolar units occur. The use of low tidal volume and limited airway pressure has improved survival in patients with acute lung ...
López Aguilar, Josefina, Villagrá, Ana, Piacentini Gómez, Enrique, Blanch Torra, Lluís   +3 more
core  

Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation [PDF]

, 2015
Introduction Direct comparison of the relative efficacy of different recruitment maneuvers (RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is difficult, due to the heterogeneity of patient populations and disease ...
Hardman, Jonathan G., Tayyba Ali, Bates, Declan G., Anup Das, Oana Cole, Cole, Oana, Marc Chikhani, Wang, Wenfei, Das, Anup, Declan G Bates, Jonathan G Hardman, Declan G. Bates, Haque, Mainul, Wenfei Wang, Jonathan G. Hardman, Bates, Declan, Chikhani, Marc, Ali, Tayyba, Mainul Haque   +18 more
core   +1 more source

Changes in stroke volume during an alveolar recruitment maneuvers through a stepwise increase in positive end expiratory pressure and transient continuous positive airway pressure in anesthetized patients. A prospective observational pilot study

Journal of Anaesthesiology Clinical Pharmacology, 2019
Background and Aims: Recruitment maneuvers may be used during anesthesia as part of perioperative protective ventilation strategy. However, the hemodynamic effect of recruitment maneuvers remain poorly documented in this setting.
Jean Luc Hanouz, Axel Coquerel, Christophe Persyn, Dorothée Radenac, Jean Louis Gérard, Marc Olivier Fischer   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Volume-controlled ventilation versus pressure-controlled ventilation and recruitment maneuvers in video-assisted thoracoscopic surgery

Gülhane Tıp Dergisi, 2023
Aims:Various ventilation strategies can be applied to prevent lung injury during one-lung ventilation (OLV). We compared intraoperative ventilation strategies in terms of haemodynamic and respiratory parameters in video-assisted thoracoscopic surgery ...
Esra Sarı, Hilal Sazak, Mehtap Tunç, Fatma Ulus, Ali Alagöz   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Alveolar recruitment maneuvers in acute lung injury/acute respiratory distress syndrome

, 2009
Mechanical ventilation can worsen lung damage in acute lung injury and acute respiratory distress syndrome. The use of low tidal volumes is one of the strategies that has been shown to reduce lung injury and improve outcomes in this situation.
Rani, Usha, Chacko, Jose
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Efficacy of Alveolar Recruitment Maneuvers in the Adult Obese Patient Undergoing General Anesthesia: A Systematic Review of the Literature [PDF]

, 2018
There are many pathophysiologic health effects associated with obesity, and the effects on normal respiratory physiology can be profound. The presence of increased adipose tissue can limit a patient’s functional residual capacity, reduce end expiratory ...
Banks, Joseph A.
core   +1 more source