Results 41 to 50 of about 2,449,254 (296)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Ano-Rectal Conditions: An Overview

, 2008
Ano-rectal diseases are arrays of disease conditions occurring within the rectum and anal canal. Diseases of the rectum and anus are common and affect a large proportion of the population.
Owoseye, A, OA Sowande, A Owoseye, Olajide, TA, Sowande, OA, TA Olajide   +5 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Association between pretreatment haemoglobin levels and morphometric characteristics of the tumour, response to neoadjuvant treatment and long-term outcomes in patients with locally advanced rectal cancers [PDF]

, 2013
Aim The study was carried out to investigate whether pretreatment haemoglobin (Hb) levels act as a biomar- ker in the management of patients with locally advanced rectal cancer.
Shabaan, A, Khan, AA, R. Glynne-Jones, Klonizakis, M, Glynne-Jones, R, A. A. Khan, M. Klonizakis, A. Shabaan   +7 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Radical surgery for non-neoplastic colonic diseases

Zaporožskij Medicinskij Žurnal, 2023
Aim. To improve the results of surgical treatment for patients with non-neoplastic colonic diseases by optimizing the choice of radical surgery extent. Materials and methods.
V. M. Melnyk
doaj   +1 more source

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients [PDF]

, 2006
Background: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible.
Mwenechanya, J, McIlleron Helen, Agbenyega, Tsiri, Molyneux, M, Olliaro, P, Miller, Raymond, Kyaw Win, Nosten Francois, Simpson, Julie A., Tembo, M, Simpson, Julie A, Ribeiro, Isabela, van Vugt, Michele, Weerasuriya, Kris, Molyneux Malcolm, Nicholas J White, Miller Raymond, Julie A Simpson, Pang, L, Pang, Lorrin, Gianni Di Perri, Simpson Julie A, White, Nicholas J., McIlleron, H, Francois Nosten, Mansor, Sharif, Perri, Gianni Di, Ward, Steve, Michele van Vugt, White, Nicholas J, Helen McIlleron, Ward Steve, Isabela Ribeiro, Sharif Mansor, Olliaro Piero, White Nicholas J, Simpson, JA, Perri, GD, Di Perri, Gianni, Di Perri, G, Piero Olliaro, Barnes, Karen I, Krudsood, S, Krishna, Sanjeev, Win, K, Navaratnam, Visweswaran, Barnes Karen I, White, NJ, van Vugt, M, Ward, S, Olliaro, Piero, Visweswaran Navaratnam, Navaratnam Visweswaran, Raymond Miller, James Mwenechanya, Molyneux, Malcolm, Sornchai Looareesuwan, Agbenyega, T, Krudsood, Srivicha, Agbenyega Tsiri, Folb, P, Mansor, S, Looareesuwan, S, van Vugt Michele, Looareesuwan, Sornchai, Perri Gianni Di, Tembo Madalitso, Lorrin Pang, Krudsood Srivicha, Gomes, M, Melba Gomes, Sanjeev Krishna, Julie A Simpson, Gomes, Melba, Win Kyaw, Navaratnam, V, Mansor Sharif, Folb Peter, Ribeiro Isabela, Madalitso Tembo, McIlleron, Helen, Weerasuriya Kris, Barnes, KI, Kris Weerasuriya, Pang Lorrin, Tembo, Madalitso, Folb, Peter, Malcolm Molyneux, Ribeiro, I, Srivicha Krudsood, Barnes, Karen I., Looareesuwan Sornchai, Mwenechanya, James, Gomes Melba, Krishna Sanjeev, Nosten, F, Tsiri Agbenyega, Karen I Barnes, Mwenechanya James, Steve Ward, Krishna, S, Peter Folb, Win, Kyaw, Weerasuriya, K, Miller, R, Nosten, Francois   +105 more
core   +2 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

A SCIENTIFIC REVIEW OF MOOLAM (ANO RECTAL DISEASES)-YUGIS VERSION [PDF]

, 2018
Worldwide, the overall prevalence of an ano rectal disease in the general population is estimated to be 4.4%. The faulty dietary pattern and life style , hereditary factors are important etiological factors of this disease.
Manikavasakam, K., Kantham, T.Lakshmi, Aishwarya, *A., Banumathi, V.   +3 more
core