Results 61 to 70 of about 2,337,549 (294)

Gene and microRNA expression predictive of tumour response in patients treated with preoperative chemoradiotherapy for rectal cancer [PDF]

, 2013
Background Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, the response to pCRT is not uniform, and there is no effective method to predict tumour response to pCRT ...
Maretto, I
core  

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Concurrent Occurrence of Rectal Adenocarcinoma and Vulvar Keratinizing Squamous Cell Carcinoma: Case Report and Literature Review

Lietuvos Chirurgija
Introduction. Vulvar carcinoma is a rare malignancy, whereas rectal cancer is a more common oncological condition. However, the simultaneous occurrence of these two diseases is exceptionally rare. Case presentation.
Odeta Laukaitytė, Gustė Brazytė, Tadas Latkauskas, Saulius Paškauskas   +3 more
doaj   +1 more source

Hyperglycemia-induced attenuation of rectal perception depends upon pattern of rectal balloon inflation. Digestive Diseases and Sciences

, 1997
This study investigated the effects of acute hyperglycemia on conscious rectal perception in response to two different rectal distension paradigms. Eleven healthy males were studied in random order on two separate days during euglycemia and hyperglycemia

core   +1 more source

Fluoroquinolone-resistant Escherichia coli, Indonesia [PDF]

, 2005
In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy ...
Mertaniasih, Ni Made, Kershof, Irma, Kuntaman, Kuntaman, Sri Lestari, Endang, Kershof, Irma M., Juliëtte A. Severin, Lestari, ES, Hadi, Usman, Kuntaman, K, Severin, Juliëtte A., Endang Sri Lestari, James R. Johnson, Lestari, Endang Sri, Verbrugh, Henri A., van Belkum, Alex, Ni Made Mertaniasih, Marijam Purwanta, Henri A. Verbrugh, Johnson, James R., Belkum, Alex, Severin, Juliette, Purwanta, Marijam, Usman Hadi, Johnson, JR, Kuntaman Kuntaman, Purwanta, M, Hadi, U, Belkum, Alex van, Irma M. Kershof, Alex van Belkum, Mertaniasih, NM, Verbrugh, Henri   +31 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Chinese science popularization guideline on the prevention and management of rectal prolapse （2026, medical personnel edition）

结直肠肛门外科
Although rectal prolapse has a relatively low prevalence among anorectal diseases, its prolonged course and high recurrence rate after treatment can significantly affect patients' daily work and life. Moreover, public awareness of rectal prolapse and the
Medical Science Popularization Branch of the Chinese Medical Doctor Association, Anorectal Surgeons Branch of the Chinese Medical Doctor Association, Anorectal Science Popularization Group of the Medical Science Popularization Branch of the Chinese Medical Doctor Association   +2 more
doaj   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source