Results 151 to 160 of about 153,838 (196)

Pelvic Exenteration for Cervical Cancer: Oncological, Morbidity and Quality of Life Outcomes

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives One third of patients who undergo definitive chemoradiotherapy for locally advanced cervical cancer develop disease recurrence. Salvage surgery in the form of pelvic exenteration (PE) may offer improved survival and possibly cure in carefully selected patients, however robust data is scarce.
Alexandra M. Peacock, Kilian G.M. Brown, Peter J. M. Lee, Kirk K. S. Austin, Christopher M. Byrne, Daniel Steffens, Michael J. Solomon   +6 more
wiley   +1 more source

Plotting the Path to Recovery: Group‐Based Trajectory Modelling of Physical Activity After Major Oncological Surgery to Predict Postoperative Outcomes

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Methods The role of early and increased activity on postoperative recovery is well established, yet the impact of its day‐to‐day variability remains unclear. This retrospective cohort study examined associations between early in‐hospital postoperative physical activity trajectories and postoperative outcomes among 218 surgical ...
Ella Jansen, Carlos de Miguel Llorente, Petra Bor, Jan Willem van den Berg, Karin Valkenet   +4 more
wiley   +1 more source

Gastrointestinal Cancer Surgery in Patients on Maintenance Hemodialysis: A Prisma Guided Systematic Review and Propensity Score Matched Cohort Analysis

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Patients receiving maintenance hemodialysis (HD) have limited physiologic reserve and high competing cardiometabolic risk, yet surgery remains central to cure for many gastrointestinal (GI) malignancies. Evidence describing oncologic surgery in this population is fragmented across cancer sites and data sources.
Ali Abdelhady, Yara Sakr, Rayner P. Cardoso, Eman Zineldin, Courtney Scaife, Marshall Baker, Erin Ward, T. Clark Gamblin   +7 more
wiley   +1 more source

Radical Resection Versus Organ‐Preserving Local Excision for Rectal Gastrointestinal Stromal Tumor: The Role of Neoadjuvant Imatinib

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Rectal gastrointestinal stromal tumors (GISTs) are rare, and their optimal surgical management remains controversial. This study compared clinicopathologic features and oncologic outcomes between total mesorectal excision (TME) and local excision (LE) to guide surgical strategy.
Byeo Lee Lim, Young Il Kim, Jong Lyul Lee, Chang Sik Yu, Hyung‐Don Kim, Min‐Hee Ryu, Chan Wook Kim   +6 more
wiley   +1 more source

Ultrasound Features Associated with Activity of Perianal Fistulas in Pediatric Patients with Crohn's Disease

Journal of Ultrasound in Medicine, EarlyView.
Objectives To evaluate the usefulness of transperineal ultrasonography (TPUS) for assessing the activity of perianal fistulas by exploring features associated with the magnetic resonance novel index for fistula imaging in Crohn's disease (MAGNIFI‐CD).
Ok Jeong Yu, Hee Mang Yoon, Ah Young Jung, Young Ah Cho, Jin Seong Lee, Seak Hee Oh, Dae Yeon Kim, Jung‐Man Namgoong, Hyunhee Kwon, Kyung Mo Kim, Pyeong Hwa Kim   +10 more
wiley   +1 more source

Integrating CT‐Based Radiomics Analysis With Serum CEA Level to Predict Neoadjuvant Chemoradiotherapy Response in Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Response to neoadjuvant chemoradiotherapy (NACRT) in locally advanced colorectal cancer (CRC) varies widely, and accurately identifying poor responders is crucial for guiding timely treatment modification. This study aimed to develop an integrated predictive model combining radiomics derived from routine radiotherapy non‐contrast planning ...
Sin‐Hua Moi, Ming‐Yii Huang, Shu‐Han Yang, Chien‐Jang Chen, Ying‐Pei Jhong, Tun‐Wei Hsu, Chien‐Chih Ke   +6 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

SERPINB9 Promotes Colorectal Cancer Liver Metastasis and Immunotherapy Resistance: Association With MHC‐I Downregulation and CD8+ T Cell Dysfunction

Medicine Bulletin, EarlyView.
ABSTRACT Background Colorectal cancer liver metastasis (CRLM) is the leading cause of mortality in colorectal cancer (CRC) patients, for which effective treatments remain limited. The mechanisms by which tumor cells evade immune surveillance and escape cytotoxic killing remain poorly understood.
Xin Liu, Wenchen Wang, Hongqian Wang, Yanshen Kuang, Baoqing Jia   +4 more
wiley   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Expert consensus on clinical trial design guidelines for FLASH radiotherapy

Precision Radiation Oncology, EarlyView.
• FLASH radiotherapy has emerged as a transformative technology due to the underlying FLASH effect. • As FLASH radiotherapy moves toward clinical application, establishing standardized trial design principles is critical. • This expert consensus provides a roadmap for rigorous clinical evaluation of FLASH radiotherapy, accelerating safe translation of ...
Hui Luo, Chen Cheng, Chengliang Yang, Bing Li, Jiandong Zhang, Jinbo Yue, Zhaoyang Lou, Hui Liu, Jing Cai, Hong Ge   +9 more
wiley   +1 more source