Results 71 to 80 of about 153,838 (196)

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

HEMATOLOGICAL PARAMETERS AND TUMOR SIZE IN RECTAL CANCER

Journal of Surgical Sciences, 2019
Rectal cancer is a pathology that still has a high incidence, mortality and morbidity all around the world. As with other types of neoplasm, researchers all around the world are attempting to find statistically significant linkages between easy and ...
O. Andronic, Alexandra Bolocan, Georgiana Radu, D.N. Păduraru, D. Ion, S.M. Oprescu   +5 more
doaj  

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Deep Learning Algorithm to Determine the Presence of Rectal Cancer from Transrectal Ultrasound Images

Life
Background: Transrectal ultrasound (TRUS) is a crucial diagnostic tool for accurately detecting rectal cancer; however, its accuracy varies with the examiner’s experience.
Min Cheol Chang, Sung Il Kang, Sohyun Kim   +2 more
doaj   +1 more source

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients [PDF]

, 2006
Background: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible.
Mwenechanya, J, McIlleron Helen, Agbenyega, Tsiri, Molyneux, M, Olliaro, P, Miller, Raymond, Kyaw Win, Nosten Francois, Simpson, Julie A., Tembo, M, Simpson, Julie A, Ribeiro, Isabela, van Vugt, Michele, Weerasuriya, Kris, Molyneux Malcolm, Nicholas J White, Miller Raymond, Julie A Simpson, Pang, L, Pang, Lorrin, Gianni Di Perri, Simpson Julie A, White, Nicholas J., McIlleron, H, Francois Nosten, Mansor, Sharif, Perri, Gianni Di, Ward, Steve, Michele van Vugt, White, Nicholas J, Helen McIlleron, Ward Steve, Isabela Ribeiro, Sharif Mansor, Olliaro Piero, White Nicholas J, Simpson, JA, Perri, GD, Di Perri, Gianni, Di Perri, G, Piero Olliaro, Barnes, Karen I, Krudsood, S, Krishna, Sanjeev, Win, K, Navaratnam, Visweswaran, Barnes Karen I, White, NJ, van Vugt, M, Ward, S, Olliaro, Piero, Visweswaran Navaratnam, Navaratnam Visweswaran, Raymond Miller, James Mwenechanya, Molyneux, Malcolm, Sornchai Looareesuwan, Agbenyega, T, Krudsood, Srivicha, Agbenyega Tsiri, Folb, P, Mansor, S, Looareesuwan, S, van Vugt Michele, Looareesuwan, Sornchai, Perri Gianni Di, Tembo Madalitso, Lorrin Pang, Krudsood Srivicha, Gomes, M, Melba Gomes, Sanjeev Krishna, Julie A Simpson, Gomes, Melba, Win Kyaw, Navaratnam, V, Mansor Sharif, Folb Peter, Ribeiro Isabela, Madalitso Tembo, McIlleron, Helen, Weerasuriya Kris, Barnes, KI, Kris Weerasuriya, Pang Lorrin, Tembo, Madalitso, Folb, Peter, Malcolm Molyneux, Ribeiro, I, Srivicha Krudsood, Barnes, Karen I., Looareesuwan Sornchai, Mwenechanya, James, Gomes Melba, Krishna Sanjeev, Nosten, F, Tsiri Agbenyega, Karen I Barnes, Mwenechanya James, Steve Ward, Krishna, S, Peter Folb, Win, Kyaw, Weerasuriya, K, Miller, R, Nosten, Francois   +105 more
core   +2 more sources

A Generalizable Multimodal Model for Treatment‐Stratified Risk and Survival Assessment under Real‐World Constraints: A Multi‐Center Study of Colorectal Cancer

Advanced Science, EarlyView.
DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao, Zheyi Ji, Chang He, Jiying Wang, Xiaoming Luo, Junyi Liu, Xiaohu Jing, Fang Yan, Yirong Chen, Linhao Qu, Sen Yang, Le Lu, Yuming Jiang, Xiyue Wang, Chengyun Dou, Junhan Zhao   +15 more
wiley   +1 more source

Cryoablation as an organ-preserving therapy for low rectal cancer a comprehensive protocol and institutional perspective

Frontiers in Oncology
Cryoablation is an interventional approach which induces localized tumor destruction. It is used to treat patients with low rectal cancer (LRC) to preserve their sphincters and avoid permanent colostomies.
Xuejun Jiang, Feng Zhou, Zujin Ji, Xinyi Lei, Fangjun Yuan   +4 more
doaj   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source