Results 61 to 70 of about 153,838 (196)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

open access: yesAdvanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang   +10 more
wiley   +1 more source

Tailoring rectal cancer surgery: Surgical approaches and anatomical insights during deep pelvic dissection for optimal outcomes in low‐lying rectal cancer

open access: yesAnnals of Gastroenterological Surgery
This review article explores advanced surgical approaches and anatomical insights for tailoring rectal cancer surgery, particularly focusing on low‐lying rectal cancer.
Youn Young Park, Nam Kyu Kim
doaj   +1 more source

Primary melanoma of the rectum: Surgical management of a rare case

open access: yesInternational Journal of Gastrointestinal Intervention
Melanoma of the rectum is a rare malignancy with an aggressive clinical course, accounting for 4% of all anorectal cancers. This malignancy most commonly affects individuals in their eighth decade of life and presents with nonspecific symptoms, such as ...
José Richard Tenazoa-Villalobos   +3 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

open access: yesAdvanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia   +13 more
wiley   +1 more source

Rectal Microbicides: Investments and Advocacy [PDF]

open access: yes, 2006
The first-ever report tracking rectal microbicide research and development expenditures, was released on April 24 by the International Rectal Microbicide Working Group (IRMWG) at a special symposium titled "Rectal Microbicides - A New Frontier in HIV ...
Cindra Feuer
core   +2 more sources

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

open access: yesAdvanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin   +9 more
wiley   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia   +15 more
wiley   +1 more source

Role of MRI in diagnosis and preoperative staging of rectal carcinoma

open access: yesAl-Azhar Assiut Medical Journal, 2019
Background and objectives High-resolution phased-array MRI is recommended as a standard imaging modality for preoperative local staging of rectal cancer with excellent soft tissue contrast, functional imaging ability, and multiplanar capability.
Mohamed F Abdelmoty   +2 more
doaj   +1 more source

Early rectal neoplasm in dual-layer spectral detector computed tomography: dual-layer spectral computed tomography (CT) images improve tumor detection and staging [PDF]

open access: yes
BackgroundEarly rectal neoplasms can be treated endoscopically with good prognosis, yet usually present with unspecific or an absence of signs and symptoms and are detected largely by invasive endoscopy with less compliance to screening.

core   +1 more source

Association between pretreatment haemoglobin levels and morphometric characteristics of the tumour, response to neoadjuvant treatment and long-term outcomes in patients with locally advanced rectal cancers [PDF]

open access: yes, 2013
Aim The study was carried out to investigate whether pretreatment haemoglobin (Hb) levels act as a biomar- ker in the management of patients with locally advanced rectal cancer.
Shabaan, A   +7 more
core   +1 more source

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