Results 191 to 200 of about 582,867 (329)

Autonomic Plexuses of the Female Sexual Organs Travel Within Pubocervical and Rectovaginal [Endopelvic] Fascia: A Rationale for ‘Nerve‐Aware’ Vaginal Prolapse Repair

Clinical Anatomy, EarlyView.
ABSTRACT The connective tissue support of female pelvic viscera—endopelvic fascia—has been studied in fetal and immunohistochemical models to demonstrate its relationship with the autonomic nerves of the female pelvis. Due to a paucity of literature examining the gross anatomical relationships between endopelvic fascia and autonomic nerves in adult ...
Stephen Magliocchetti, Benjamin Laxer, Leyla Spennato, Norah Alturki, Queena Chou, Tyler S. Beveridge   +5 more
wiley   +1 more source

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications, EarlyView.
Abstract Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target. Methods RNA m1A levels were assessed through liquid chromatography‐mass spectrometry.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
wiley   +1 more source

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Tocotrienols: A Review From Source to Therapeutic Applications

Food Frontiers, EarlyView.
Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño, Nidia Casas‐Forero, Andres‐Felipe Garzón‐Méndez, Dalí‐Aleixandra Rojas‐Díaz, Mary‐Luz Olivares‐Tenorio, Hernan‐Mauricio Romero, Jesús‐Alberto García‐Núñez   +6 more
wiley   +1 more source

Rectal large cell neuroendocrine carcinoma. [PDF]

Oxf Med Case Reports
Drakos PA, Prountzopoulou AA, Totskas E, Stamou K.   +3 more
europepmc   +1 more source

Medulla Tetrapanacis Water Extract Ameliorates Dextran Sulfate Sodium‐Induced Ulcerative Colitis by Reprogramming Macrophage Polarization and Maintaining Intestinal Barrier Integrity

Food Frontiers, EarlyView.
The protective effects of Medulla Tetrapanacis (MT) water extract on dextran sulfate sodium‐induced ulcerative colitis (UC) were examined both in vivo (mouse and zebrafish) and in vitro. The effect of MT on UC was mediated by regulating macrophage polarization, ameliorating oxidative stress, and preserving an intact intestinal barrier. The effect of MT
Yanfen Cheng, Carsten Tsun‐Ka Kwok, Zi‐Wen Yang, Xi Feng, George Pak‐Heng Leung, Simon Ming‐Yuen Lee, Franklin Wang‐Ngai Chow, Lele Zhang, Daniel Kam‐Wah Mok, Sai‐Wang Seto, Jingjing Li   +10 more
wiley   +1 more source

Diagnostic Efficacy and Correlation of Intravoxel Incoherent Motion (IVIM) and Contrast-Enhanced (CE) MRI Perfusion Parameters in Oncology Imaging: A Systematic Review and Meta-Analysis. [PDF]

Int J Biomed Imaging
S A, Kadavigere R, P S P, Singh D, Priyanka, Pires T, Kumar D, Pendem S.   +7 more
europepmc   +1 more source

Endoscopic resection of submucosal tumors [PDF]

, 2015
Bhandari, Pradeep, Longcroft-wheaton, Gaius   +1 more
core   +2 more sources

Integrated In Vitro, In Vivo, and In Silico Study Reveals Gut‐Protective Effects of Myricitrin From Chinese Bayberry Leaves

Food Frontiers, EarlyView.
High‐purity myricitrin from Chinese bayberry leaves alleviates colonic inflammation by preserving epithelial barrier integrity and reshaping gut microbiota composition. ABSTRACT Polyphenols have been widely recognized for their ability to modulate the host inflammatory response and orchestrate the intestinal microenvironment.
Ji‐Min Lv, Wei Quan, Xiao‐Hua Cheng, Jing Zhu, Aliyu Idris Muhammad, Wang‐Ting Zhou, Xing‐Jiang Qi, Chong‐De Sun   +7 more
wiley   +1 more source