Results 81 to 90 of about 165,545 (324)

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

open access: yesAdvanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang   +15 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

open access: yesAdvanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li   +8 more
wiley   +1 more source

Oral application of L-menthol in the heat: From pleasure to performance [PDF]

open access: yes, 2019
When menthol is applied to the oral cavity it presents with a familiar refreshing sensation and cooling mint flavour. This may be deemed hedonic in some individuals, but may cause irritation in others.
Barwood, Martin   +3 more
core  

The effects of ice vest pre-cooling on skin blood flow at rest and during exercise in the heat [PDF]

open access: yes, 2015
© 2015 The Authors. Published by BMC. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1186/2046-7648-4-S1-A127Ice vest
JS Petrofsky, MJ Price, NLA Ramanathan
core   +6 more sources

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

open access: yesAdvanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli   +16 more
wiley   +1 more source

Oral temperature of preweaning dairy heifers: Sensitivity and specificity at detecting individuals with pyrexia

open access: yesJDS Communications
Change in body temperature can be an early indicator of illness. In calves, body temperature is routinely estimated from rectal temperature measurement.
K.R.K. Gottwald   +3 more
doaj   +1 more source

Characteristics of Piglets Born by Two Highly Prolific Sow Hybrids

open access: yesFrontiers in Veterinary Science, 2020
High piglet mortality constitutes a welfare challenge in Danish organic pig production with almost one in three piglets dying before weaning. Piglet characteristics such as birth weight, rectal temperature and intrauterine growth restriction (IUGR ...
Sarah-Lina Aagaard Schild   +5 more
doaj   +1 more source

Non-Invasive Body Temperature Measurement of Wild Chimpanzees Using Fecal Temperature Decline [PDF]

open access: yes, 2009
New methods are required to increase our understanding of pathologic processes in wild mammals. We developed a noninvasive field method to estimate the body temperature of wild living chimpanzees habituated to humans, based on statistically fitting ...
Boesch, Christophe   +4 more
core   +2 more sources

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

open access: yesAdvanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika   +22 more
wiley   +1 more source

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