Results 91 to 100 of about 393,664 (428)

Sexually transmitted infections of the anus and rectum.

open access: yesWorld Journal of Gastroenterology, 2014
Sexually transmitted infections (STIs) represent a significant public health concern. Several STIs, once thought to be on the verge of extinction, have recently reemerged.
R. Assi   +4 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Rectal Squamous Cell Carcinoma: A Case Report Of A Rare Histology [PDF]

open access: yesIranian Journal of Colorectal Research, 2019
The rectum is an unusual and unlikely site for squamous carcinoma of the gastrointestinal tract. The clinicalpresentation of this rare histology though, is similar to adenocarcinoma rectum.
Sankal Psingh   +5 more
doaj  

Disseminated lung cancer presenting as a rectal mass

open access: yesEuropean Clinical Respiratory Journal, 2016
Primary lung cancer is the leading cause of cancer-related deaths globally, and approximately 50% had metastatic disease at the time of diagnosis. A rectal mass and unintended weight loss are common manifestations of rectal cancer.
Mia M. Noergaard   +2 more
doaj   +1 more source

Interstitial cell network volume is reduced in the terminal bowel of ageing mice [PDF]

open access: yes, 2018
Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal impaction and incontinence.
Gamage, Prasanna P. K. M.   +4 more
core   +3 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

open access: yesMolecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen   +5 more
wiley   +1 more source

Tumor Macroscopic Morphology Is an Important Prognostic Factor in Predicting Chemotherapeutic Efficacy and Clinical Outcomes of Patients With Colorectal Neuroendocrine Neoplasms, One Multicenter Retrospective Cohort Study

open access: yesFrontiers in Endocrinology, 2021
Background and AimsLocally advanced and metastatic colorectal neuroendocrine neoplasm (NEN) is a rare disease with a dismal prognosis. We aimed to explore the value of the macroscopic morphology of NENs in the management of TNM stage II-IV colorectal ...
Zhijie Wang, Ke An, Rui Li, Qian Liu
doaj   +1 more source

Colonoscopy Landmark Detection using Vision Transformers [PDF]

open access: yesarXiv, 2022
Colonoscopy is a routine outpatient procedure used to examine the colon and rectum for any abnormalities including polyps, diverticula and narrowing of colon structures. A significant amount of the clinician's time is spent in post-processing snapshots taken during the colonoscopy procedure, for maintaining medical records or further investigation ...
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

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