Results 91 to 100 of about 438,287 (347)

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Uncertainty in multitask learning: joint representations for probabilistic MR-only radiotherapy planning

, 2018
Multi-task neural network architectures provide a mechanism that jointly integrates information from distinct sources. It is ideal in the context of MR-only radiotherapy planning as it can jointly regress a synthetic CT (synCT) scan and segment organs-at-
Alexander, Daniel C., Bragman, Felix J. S., Cardoso, M. Jorge, Eaton-Rosen, Zach, Hawkes, David J., Li, Wenqi, McClelland, Jamie R., Ourselin, Sebastien, Tanno, Ryutaro   +8 more
core   +1 more source

SURGERY OF THE ANUS, ANAL CANAL AND RECTUM [PDF]

, 1958
E. S. R. Hughes
openalex   +1 more source

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Advanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Zhu   +17 more
wiley   +1 more source

ABDOMINO-PERINEAL EXCISION OF THE RECTUM BY A NEW METHOD [PDF]

, 1903
L. B. Aldrich-Blake
openalex   +1 more source

Villous Adenoma of Rectum. Carcinoma of Rectum [PDF]

Proceedings of the Royal Society of Medicine, 1967
C G Davis, L R DeJode
openaire   +3 more sources

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

Advanced Science, EarlyView.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li, Yingjiao Ju, Chenjie Xu, Shixiang Ma, Lan Sun, Qingdong Guo, Mingyuan Liu, Yibin Xie, Li Min   +8 more
wiley   +1 more source

Ein Fall von Stenose des Rectum durch metastatisches Karzinom bei gleichzeitigem metastasierendem Myelom [PDF]

, 1908
H. Toyosumi
openalex   +1 more source

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source