Results 101 to 110 of about 433,216 (318)

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Rectum: Gerade heraus. Von Studierenden für Studierende Jg. 2019/2020, H. 1 [PDF]

, 2019
Das RECTUM ist das Studierendenmagazin der Veterinärmedizinischen Universität ...
Hochschülerinnen- und Hochschülerschaft der Veterinärmedizinischen Universität Wien
core  

Rectum: Gerade heraus. Von Studierenden für Studierende Jg. 47 (2022/2023), H. 2 [PDF]

, 2022
Das RECTUM ist das Studierendenmagazin der Veterinärmedizinischen Universität ...
Hochschülerinnen- und Hochschülerschaft der Veterinärmedizinischen Universität Wien
core  

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Adherent Escherichia coli in colorectal mucosal biopsies: A histological and ultrastructural evaluation

Indian Journal of Pathology and Microbiology, 2012
Background: Colorectal mucosal biopsies occasionally demonstrate the presence of bacteria adherent to the epithelium. This study evaluated the histological and ultrastructural correlates of such bacterial adherence.
Susama Patra, Subash C Samal, Gagandeep Kang, Anna Pulimood, Minnie Mathan, Balakrishnan S Ramakrishna   +5 more
doaj   +1 more source

Rectum: Gerade heraus. Von Studierenden für Studierende Jg. 2018/2019, H. 3 [PDF]

, 2019
Das RECTUM ist das Studierendenmagazin der Veterinärmedizinischen Universität ...
Hochschülerinnen- und Hochschülerschaft der Veterinärmedizinischen Universität Wien
core  

Rectum: Gerade heraus. Von Studierenden für Studierende Jg. 48 (2023/2024), H. 1 [PDF]

, 2023
Das RECTUM ist das Studierendenmagazin der Veterinärmedizinischen Universität ...
Hochschülerinnen- und Hochschülerschaft der Veterinärmedizinischen Universität Wien
core  

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Rectum: Richtige Erklärungen Collegiale Tendenzen Und Meinungen Jg. 2014/2015, H. 3 [PDF]

, 2015
Das RECTUM ist das Studierendenmagazin der Veterinärmedizinischen Universität ...
Hochschülerinnen- und Hochschülerschaft der Veterinärmedizinischen Universität Wien
core