Results 41 to 50 of about 120,359 (315)

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A recurrence relation for the square root

Journal of Approximation Theory, 1973
AbstractThe behavior of the sequence xn + 1 = xn(3N − xn2)2N is studied for N > 0 and varying real x0. When 0 < x0 < (3N)12 the sequence converges quadratically to N12. When x0 > (5N)12 the sequence oscillates infinitely. There is an increasing sequence βr, with β−1 = (3N)12 which converges to (5N)12 and is such that when βr < x0 < βr + 1 the sequence {
John Todd, W.G Hwang
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

New formulas of convolved Pell polynomials

AIMS Mathematics
The article investigates a class of polynomials known as convolved Pell polynomials. This class generalizes the standard class of Pell polynomials. New formulas related to convolved Pell polynomials are established.
Waleed Mohamed Abd-Elhameed, Anna Napoli   +1 more
doaj   +1 more source

Towards the Centenary of Sheffer Polynomial Sequences: Old and Recent Results

Mathematics, 2022
Sheffer’s work is about to turn 100 years after its publication. In reporting this important event, we recall some interesting old and recent results, aware of the incompleteness of the wide existing literature. Particularly, we recall Sheffer’s approach,
Francesco Aldo Costabile, Maria Italia Gualtieri, Anna Napoli   +2 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Number of spanning trees of some families of graphs generated by a triangle

Journal of Taibah University for Science, 2019
In mathematics, one always tries to get new structures from given ones. This also applies to the realm of graphs, where one can generate many new graphs from a given set of graphs.
S. N. Daoud
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Some Determinantal Expressions and Recurrence Relations of the Bernoulli Polynomials

Mathematics, 2016
In the paper, the authors recall some known determinantal expressions in terms of the Hessenberg determinants for the Bernoulli numbers and polynomials, find alternative determinantal expressions in terms of the Hessenberg determinants for the Bernoulli ...
Feng Qi, Bai-Ni Guo
doaj   +1 more source