Results 141 to 150 of about 162,152 (315)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Treatment for recurrent hairy cell leukemia.

Терапевтический архив, 2012
Aim. To give data on the frequency of recurrent hairy cell leukemia (HCL) and to characterize the immediate and late results of its treatment in this group of patients. Materials and methods.
L S Al'-Radi, A V Pivnik, B V Zingerman, S K Kravchenko   +3 more
doaj  

Patterns of prostate recurrence after focal salvage prostate brachytherapy for radiorecurrent prostate cancer

Clinical and Translational Radiation Oncology
Background and purpose: Focal high-dose-rate (HDR) salvage brachytherapy has emerged as a treatment for radiorecurrent prostate cancer. This study aims to evaluate patterns of recurrence after focal salvage brachytherapy and to assess the adequacy of ...
Alba Domínguez Domínguez, Niels den Haan, Jan Wiersma, Josephina C.C. Koppes, Karel A. Hinnen, Bradley R. Pieters   +5 more
doaj   +1 more source

Recurrences after gene therapy with lentiviral vectors.

, 2013
Recurrences after gene therapy with lentiviral vectors.
Rolf Bjerkvig (68682), Philipp Euskirchen (371673), Kai Ove Skaftnesmo (148358), Peter C. Huszthy (325266), Hrvoje Miletic (211715), Dorothee von Laer (307452), Oleg Tsinkalovsky (371670), Tsanan Giroglou (371669)   +7 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Some recurrences for sums of powers of binomial coefficients

, 1987
Recently, interest has been sparked in recurrences for sums of powers of binomial coefficients.
Perlstadt, Marci A.
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A simple Hidden Markov Model for midbrain dopaminergic neurons

, 2009
Poster presentation: Introduction Dopaminergic neurons in the midbrain show a variety of firing patterns, ranging from very regular firing pacemaker cells to bursty and irregular neurons.
Gerhard, Felipe, Roeper, Jochen, Felipe Gerhard, Schneider, Gaby, Gaby Schneider, Schiemann, Julia, Jochen Roeper, Julia Schiemann   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

PATHOGENESIS, PREVENTION OF RECURRENCES AND OUTCOME OF FEBRILE SEIZURES PATHOGENESIS, PREVENTION OF RECURRENCES AND OUTCOME OF FEBRILE SEIZURES

, 2020
Febrile seizures (FS) occur in 2-5% of children. Their pathogenesis is unknown. Elevated levels of prostaglandins (PG) have been found in cerebrospinal fluid after such seizures, and a third of all patients have recurrences.
Oul U, ; Ou Lun Yl Iopi Of Oulu, Sto
core