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[Genetics of recurrent airway obstruction (RAO)].

DTW. Deutsche tierarztliche Wochenschrift, 2008
Recurrent airway obstruction (RAO) is a multifactorial and polygenic disease. Affected horses are typically 7 years of age or older and show exercise intolerance, increased breathing effort, coughing, airway neutrophilia, mucus accumulation and hyperreactivity as well as cholinergic bronchospasm.
Gerber, Vinzenz   +9 more
openaire   +2 more sources

Recurrent Otitis and Upper Airway Obstruction

2019
Metabolic checkpoint kinase mTOR, is activated by PI3K, and has a prominent role in promoting dynamic changes in T cell metabolism Gain-of-function mutation in PI3K gene leads to increased mTOR function, which in turn can cause ...
Narges Eslami   +2 more
openaire   +1 more source

In vitro responses of airway smooth muscle from horses with recurrent airway obstruction

Pulmonary Pharmacology, 1991
The in vitro contractile and relaxant responses of tracheal smooth muscle strips (TSM) and third-generation bronchi (3B) of control horses and horses with recurrent obstructive disease (heaves) were compared. Acetylcholine (ACH) sensitivity of the diseased tissues was less than that of tissues from control horses, especially at the level of the third ...
R V, Broadstone   +3 more
openaire   +2 more sources

Environment and prednisone interactions in the treatment of recurrent airway obstruction (heaves)

Equine Veterinary Journal, 2000
Summary Recurrent airway obstruction (RAO) or heaves is a manifestation of a hypersensitivity to dust, moulds, and spores in the environment of a susceptible horse. Although in the majority of RAO‐affected horses, clinical remission can be achieved by keeping horses at pasture to reduce their allergen exposure, this often is not ...
C A, Jackson   +3 more
openaire   +2 more sources

Intravenous histamine administration in ponies with recurrent airway obstruction (heaves)

American Journal of Veterinary Research, 1985
SUMMARY Pulmonary function and airway reactivity to iv histamine were measured in a group of ponies with a history of recurrent airway obstruction (heaves) and their age-, weight-, and gender-matched controls. Ponies were studied during a period of clinical remission (period A), after exposure to a barn environment (period B), and twice during a 2-week
F J, Derksen   +4 more
openaire   +2 more sources

Efficacy of oral and intravenous dexamethasone in horses with recurrent airway obstruction

Equine Veterinary Journal, 2004
Summary Reasons for performing study : Although the efficacy of dexamethasone for the treatment of recurrent airway obstruction (RAO) has been documented, the speed of onset of effect and duration of action are unknown, as is the efficacy of orally administered dexamethasone with or without ...
C J, Cornelisse   +5 more
openaire   +2 more sources

Expression of thymic stromal lymphopoietin in equine recurrent airway obstruction

Veterinary Immunology and Immunopathology, 2012
Thymic stromal lymphopoietin (TSLP) is a cytokine involved in lymphocyte development. In humans and mice, TSLP drives the differentiation of T helper 2 (Th2) cells and the development of allergic inflammation. The equine TSLP gene has been previously identified and characterized, but its role in the pathogenesis of equine allergic diseases is not known.
Klukowska-Rötzler Jolanta   +6 more
openaire   +4 more sources

Recurrent airway obstruction in horses

2006
La Obstrucción Recurrente de las Vías Aéreas (ORVA) es un proceso inflamatorio como respuesta a una hipersensibilidad debida a la inhalación de agentes alergenos, la cual se caracteriza por una inflamación de la vías aéreas, acumulación de mucus y una obstrucción reversible debido a la hipersensibilidad bronquial.
Morán, G., Araya, O., Folch, H.
openaire   +1 more source

Equine recurrent airway obstruction: pathogenesis, diagnosis, and patient management

Veterinary Clinics of North America: Equine Practice, 2002
Recurrent airway obstruction is a condition that affects some older horses maintained in confinement. Clinical signs range from exercise intolerance with occasional cough to dyspnea at rest. Bronchoalveolar lavage cytology is characterized by neutrophilic leukocytosis (15%-85%) and is recommended for making the diagnosis in horses with mild to moderate
Elizabeth, Davis, Bonnie R, Rush
openaire   +2 more sources

Airway Obstruction in Adults With Recurrent Respiratory Infections and IgG Deficiency

Chest, 1994
In 42 adults with recurrent respiratory infections (RRI) and common variable immunodeficiency or immunoglobulin G (IgG) subclass deficiency, the results of pulmonary function tests were related to factors apt to produce airway obstruction: serum concentration of IgG and IgG subclasses, various features of acute RRI (number/year, time from onset to ...
openaire   +2 more sources

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