Results 61 to 70 of about 240,394 (261)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Bifurcation in a Discrete-Time Piecewise Constant Dynamical System
Discrete Dynamics in Nature and Society, 2013 The study of recurrent neural networks with piecewise constant transition or control functions has attracted much attention recently because they can be used to simulate many physical phenomena.
Chenmin Hou, Sui Sun Cheng
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Modeling Belt-Servomechanism by Chebyshev Functional Recurrent Neuro-Fuzzy Network
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2008 A novel Chebyshev functional recurrent neuro-fuzzy (CFRNF) network is developed from a combination of the Takagi-Sugeno-Kang (TSK) fuzzy model and the Chebyshev recurrent neural network (CRNN).
Yuan-Ruey HUANG +3 more
doaj +1 more source
Green's functions of recurrence relations with reflection [PDF]
Journal of Mathematical Analysis and Applications, 2019 In this work we develop an algebraic theory of linear recurrence equations and systems with constant coefficients and reflection. We obtain explicit solutions and the Green's functions associated to different problems under general linear boundary conditions.
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Distinctive Lexical Patterns in Russian Patient Information Leaflets: A Corpus-Driven Study
Russian journal of linguistics: Vestnik RUDN, 2019 This methodologically-oriented corpus-driven study focuses on distinctive patterns of language use in a specialized text type, namely Russian patient information leaflets.
Łukasz Grabowski
doaj +1 more source
Seeking functions for spinal recurrent inhibition
The Journal of Physiology, 2008 In this issue of The Journal of Physiology, Lamy et al. (2008) describe a rhythmic modulation of recurrent inhibition during walking in man. This provides some insight into the function of recurrent inhibition, first described by Renshaw (1941) as an inhibition of cat motoneurones produced by antidromic stimulation of the axons of neighbouring ...
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Contact problem of torsion of a multilayer base with elastic connections between layers
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014 Torsion of a multilayer base with elastic connections between layers by cylindrical punch with a flat sole was considered. The Hankel integral transform of the first order and the method of the compliance functions were used.
Nina N Antonenko, Igor G Velichko
doaj +1 more source