Is there an advantage of using genomic information to estimate gametic variances and improve recurrent selection in animal populations? [PDF]
Genet Sel EvolElsen JM, Raoul J, Gilbert H.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Fifty years of recurrent selection in the Iowa stiff stalk synthetic maize population
, 1992 Recurrent selection is a breeding procedure designed to increase the frequency of favorable alleles in a population. Increasing the frequency of favorable alleles will increase the probability of obtaining surerior inbred line.s for use in hybrids.
Lamkey, Kendall
core
Genomic-inferred cross-selection methods for multi-trait improvement in a recurrent selection breeding program. [PDF]
Plant MethodsAtanda SA, Bandillo N.
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Multiple Resistance Evolution in Bipyridylium-Resistant Epilobium ciliatum After Recurrent Selection. [PDF]
Front Plant Sci, 2018 Tahmasebi BK +7 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Alternative strategies of recurrent selection for seed yield of soybean
, 2014 Recurrent selection programs can be manipulated by varying either the extensiveness of testing used to identify superior lines or the number of intermating generations conducted among the superior lines between cycles of selection.
Fehr, WR, Guimarães, Elcio Perpétuo
core
Cross potential selection: a proposal for optimizing crossing combinations in recurrent selection using the usefulness criterion of future inbred lines. [PDF]
G3 (Bethesda)Sakurai K +4 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source