Results 161 to 170 of about 347,214 (307)

Population Improvement Through Recurrent Selection in Rice. Prospect for Maker Assisted Recurrent Selection and Genome-Wide Selection. W011 [PDF]

, 2012
Since 1992, we have been carrying out an upland rice breeding program for Latin American and the Caribbean based on the improvement of synthetic populations of broad genetic diversity through recurrent selection (RS).
Ospina, Yolima, Martinez, César. P, Châtel, Marc, Courtois, Brigitte, Guimaraes, Elcio Perpetuo, Tohmé, Joe, Cao, Tuong-Vi, Ahmadi, Nourollah, Grenier, Cécile   +8 more
core  

Optimal cross selection for long-term genetic gain in two-part programs with rapid recurrent genomic selection

, 2017
This study evaluates optimal cross selection for balancing selection and maintenance of genetic diversity in two-part plant breeding programs with rapid recurrent genomic selection.
John M. Hickey, R. Chris Gaynor, Gregor Gorjanc   +2 more
core   +1 more source

Recurrent selection in Grapevine breeding

, 1981
La nécessité de préserver la variabilité génétique au cours des programmes de sélection incite à concevoir une stratégie d’amélioration de la Vigne à long terme dans laquelle la sélection de nouvelles variétés est menée parallèlement à l’amélioration du matériel servant de base à cette sélection.
Bouquet, A., Truel, P., Wagner, Richard
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Breeding Top Genotypes and Accelerating Response to Recurrent Selection by Selecting Parents with Greater Gametic Variance. [PDF]

Genetics, 2020
Bijma P, Wientjes YCJ, Calus MPL.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The UEDIN English ASR System for the IWSLT 2013 Evaluation

, 2013
This paper describes the University of Edinburgh (UEDIN) English ASR system for the IWSLT 2013 Evaluation. Notable features of the system include deep neural network acoustic models in both tandem and hybrid configuration, cross-domain adaptation with ...
Renals, Steve, Birch, Alexandra, McInnes, Fergus, Bell, Peter, Gangireddy, Siva Reddy, Sinclair, Mark   +5 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source